离心调控对嗅觉系统β振荡同步性的影响  

Influence of centrifugal modulation on β-band coherence in olfactory system

作　　者：王莉[1,2] 龚玲[1,2] 张思南[3] 李博[1,2] 刘青[1] 徐富强[1,4] 

机构地区：[1]中国科学院武汉物理与数学研究所,波谱与原子分子物理国家重点实验室,生物磁共振分析重点实验室,武汉430071 [2]中国科学院大学,北京100049 [3]武汉大学生命科学学院,武汉430071 [4]武汉光电国家实验室,武汉430074

出　　处：《华中师范大学学报（自然科学版）》2014年第4期554-558,共5页Journal of Central China Normal University：Natural Sciences

基　　金：国家自然科学基金项目(91132307;31100799;20921004);科技部支撑计划项目(2012BAI23B02);中国科学院战略性先导科技专项(XDB02050005)

摘　　要：通过戊巴比妥钠麻醉和Go/No-go气味辨别训练改变清醒小鼠的脑状态,探讨离心调控对同侧的嗅球和前梨状皮层之间β振荡同步性的影响.研究结果表明:相对于清醒状态,麻醉和训练后自发β振荡的同步性分别有所下降和上升;此外,麻醉后气味诱发β振荡的同步性有所下降,而训练后气味诱发β振荡的同步性受到气味意义的影响.结果提示,离心纤维投射可以动态地调控嗅球和前梨状皮层之间β振荡的同步性,这对进一步认识大脑的功能活动有一定的帮助.Among the various cortical rhythms,β oscillations（15-35Hz） reflect connections of a larger-scale network.The functional connectivity of two brain areas could be modulated by centrifugal projection.However,the influence of centrifugal modulation on theβ-band coherence among different brain areas is still unclear.In this study,the brain states of awake mice were altered by anesthetizing and Go/No-go behavioral training,and the influence of centrifugal modulation on the coherence forβ oscillations between the ipsilateral olfactory bulb and anterior piriform cortex were analyzed.Our results demonstrate that,compared with the awake mice,the spontaneous β-band coherence goes down in the anesthetized ones,yet goes up in the trained ones.Besides,the odor-induced β-band coherence goes down in the anesthetized ones,yet dependent on odor values in the trained ones.These data suggest that theβ-band coherence between the olfactory bulb and anterior piriform cortex could be dynamically modulated by centrifugal projection.This may help in further study on the brain function.

关 键 词：离心调控 嗅球 前梨状皮层 β振荡 同步性 

分 类 号：Q4[生物学—生理学] Q189