基于柠檬酸的可降解生物弹性体的合成与性能  

Synthesis and properties of citric acid-based degradable bioelastomers

作　　者：王全忠[1] 王筠[1] 丁涛[2] 谢建平[1] 豆瑞霞[1] 安贝贝[1] 

机构地区：[1]周口师范学院化学化工学院,河南周口466001 [2]河南大学化学化工学院,河南开封475001

出　　处：《合成橡胶工业》2014年第4期294-298,共5页China Synthetic Rubber Industry

基　　金：河南省教育厅科学技术重点项目(13 A 150101);周口师范学院2014年度青年科研基金资助项目(zknuc 0212);河南省科技厅软科学研究项目(132400411312)

摘　　要：利用一缩二乙二醇与丁二酸反应制备低相对分子质量的聚一缩二乙二醇丁二酸酯，通过该聚酯二元醇与柠檬酸进行熔融缩聚反应得到了一种网络型聚醚酯生物弹性体材料。该材料为透明柔软的弹性体材料，无定形态，玻璃化转变温度低于-5℃；通过调节反应单体的摩尔比及控制预聚物的后期交联固化时间可以实现材料力学性能可调（拉伸强度1.86～4.62 MPa，扯断伸长率190％～359％）及降解性能可控（降解完全所需时间为4～14 d）；该弹性体作为生物材料具有较好的亲水性能和吸水性能，且在pH值分别为7.4的模拟体液和1.0的模拟胃液中具有溶胀-收缩可逆性。A kind of network polyester bioelastomer poly [ （ ethylene diglycol-succinate ）-citrate ] （ PESC-I） was synthesized by melt polycondensation reaction between citric acid and poly （ ethylene diglycol-succinate ） , which was prepared with ethylene diglycol and succinic acid.The results showed that PESC-I was an amorphous , transparent and flexible elastomer with glass transition temperature below-5 ℃.The mechanical and biodegradable properties of PESC-I could be modulated by changing the monomers ratio and post-polymerization time in the range of tensile strength from 1.86 MPa to 4.62 MPa, elongation at break from 190%to 359%and complete degradation time in vitro from 4 d to 14 d.The PESC-I possessed better hydrophilic performance and water absorption property , and showed swelling-shrinkage reversibility when soaked in the buffer solutions of pH value 7.4 and 1.0 alternately.

关 键 词：聚酯 生物弹性体 柠檬酸 可降解性能 力学性能 

分 类 号：TQ334.1[化学工程—橡胶工业]