新疆哈萨克族人群遗传性易栓症流行病学调查  

Epidemiological survey on hereditary thrombophilia in Xinjiang Kazak population

作　　者：朱锋[1] 戈小虎[1] 慈红波[1] 田广磊[1] 姜孝奎[1] 王秉林[1] 

机构地区：[1]新疆维吾尔自治区人民医院血管外科,乌鲁木齐830001

出　　处：《中华实用诊断与治疗杂志》2014年第7期638-640,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(81060032)

摘　　要：目的分析新疆哈萨克族人群遗传性易栓症的患病率及其影响因素。方法检测1005例伊犁哈萨克自治州常住哈萨克族人群抗凝血酶Ⅲ、蛋白C、蛋白s活性及活化C蛋白抵抗值，分析该人群遗传性易栓症患病情况及相关因素。结果1005例新疆哈萨克族人遗传性易栓症患病率为31．0％，抗凝血酶Ⅲ缺乏症、蛋白C缺乏症、蛋白S缺乏症及活化C蛋白抵抗患病率分别为16．4％、14．9％、20．6％和7．8％；男性人群蛋白c、蛋白S活性值与女性人群比较差异有统计学意义（P〈0．05）；哈萨克族人群遗传性易栓症患病率在年龄、吸烟量及新鲜蔬菜摄人量上比较差异有统计学意义（P〈0．05）；吸烟量、年龄、新鲜蔬菜摄入量是哈萨克族人群遗传性易栓症的影响因素（OR=1．216，95％CI：1．061～1．393，P=0．005；OR=1．261，95％CI：1．U0～1.433，P=0．000；OR=0．665，95％CI：0．547～0．808，P=0．000）。结论新疆哈萨克族人群遗传性易栓症患病率较高，高龄、吸烟量大及新鲜蔬菜摄入量少是其影响因素。Objective To investigate the prevalence of hereditary thrombophilia and the influencing factors in Xinjiang Kazak population. Methods The levels of antithrombin III （AT-III）, protein C, protein S activity and activated protein C resistance （APCR） were detected in 1 005 Kazak permanent residents in Ill Kazak Autonomous Prefecture to analyze the prevalence of hereditary thrombophilia and the related factors. Results The prevalence of hereditary thrombophilia was 31.0% in 1 005 Kazak permanent residents. The prevalences of deficiency of AT-III , protein C, protein S and APCR were 16.4%, 14.9%, 20.6% and 7.8%, respectively. There were significant differences protein C, protein S activity value between males and females （P〈0.05）. There were significant differences in age, smoking and intake of fresh vegetables were statistically significant differences in Kazak hereditary thrombophilia population （P〈 0.05）. Smoking, age and intake of fresh vegetables were the influencing factors for Xinjiang Kazak population （OR= 1. 216, 95%CI： 1. 061 to 1. 393, P=0. 005; OR=1. 261, 95% CI： 1. 110 to 1. 433, P=0. 000; OR=0. 665, 95% CI： 0. 547 to 0. 808, P=0. 000）. Conclusions The prevalence of hereditary thrombophilia in Kazak population is high. Smoking, age and insufficient intake of fresh vegetables are the definitely influencing factors for hereditary thrombophilia.

关 键 词：遗传性易栓症 流行病学 患病率 影响因素 

分 类 号：R543[医药卫生—心血管疾病]