血清抗内皮细胞抗体与瘦素水平对子痫前期的预测价值  

Value of serum antiendothelial cell antibody and leptin to the prediction of preeclampsia

作　　者：杜欣莹[1] 王倩 

机构地区：[1]潍坊市人民医院产科,山东潍坊261041 [2]潍坊市中心血站质控科,山东潍坊261043

出　　处：《中华实用诊断与治疗杂志》2014年第7期645-646,共2页Journal of Chinese Practical Diagnosis and Therapy

摘　　要：目的探讨外周血抗内皮细胞抗体(antiendothelial cell antibodies,AECA)与瘦素的相关性及其在子痫前期(preeclampsia,PE)发病中的作用。方法 20例子痫前期孕妇为观察组,20例正常晚期孕妇为对照组,采用ELISA法检测2组外周血AECA及瘦素水平,ROC曲线分析其诊断子痫前期的价值。结果对照组血清AECE和瘦素水平((49.92±13.09)pmol/L和(23.65±5.24)μg/L)高于观察组((26.38±17.83)pmol/L和(14.33±5.35)μg/L),差异均有统计学意义(P<0.05);观察组血清AECA水平与瘦素水平呈正相关(r=0.463,P=0.010);AECA>57.7pmol/L时诊断子痫前期的灵敏度为90%,特异度为90%;瘦素>17.05μg/L时诊断子痫前期的灵敏度为80%,特异度为80%。结论血清AECA、瘦素水平升高可能通过血管内皮损伤与炎症反应参与子痫前期的发病。Objective To explore the relationship between serum antiendothelial cell antibody （AECA） and leptin and their role in the development of preeclampsia. Methods The levels of AECA and leptin were detected by ELISA technique in 20 patients with preeclampsia （observation group） and 20 normal pregnant women （control group）. ROC curve analysis was used to evaluate the value of AECA and leptin to the diagnosis of preeclampsia. Results The levels of AECE and l eptin were higher in control group （（49.92±13.09）pmol/L, （23.65 ± 5.24） μg/L） than those in observation group （（26.38 ± 17. 83） pmol/L, （ 14. 33 ± 5.35）μg/L） （P〈0.05）. AECE was positively correlated with leptin in observation group （r= 0. 463, P= 0. 010）. The sensitivity and specificity for preeclampsia were 90% when serum AECA 〉57.7 pmol/L, and were 80% when serum leptin 〉17.05 μg/L. Conclusions The increased AECA and leptin levels participate the development of preeclampsia by inducing the endothelial damage and inflammatory response.

关 键 词：子痫前期 外周血抗内皮细胞抗体 瘦素 

分 类 号：R714.244[医药卫生—妇产科学]