转录因子Ets-1和基质金属蛋白酶-9在胎膜早破中表达意义  

Expression and significance of Ets-1 and matrix metalloproteinase-9 in the premature ruptured of membranes

作　　者：李雁[1] 陈曼诗[1] 曾晓娟[1] 刘福英[1] 

机构地区：[1]深圳市福田区人民医院妇产科,广东深圳518033

出　　处：《中华实用诊断与治疗杂志》2014年第7期658-659,共2页Journal of Chinese Practical Diagnosis and Therapy

基　　金：广东省深圳市科技计划项目(201003238)

摘　　要：目的探讨转录因子Ets-1和基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)在胎膜早破中的表达和作用。方法胎膜早破孕妇57例(胎膜早破组)和正常足月孕妇50例(对照组),采用免疫组织化学SP法检测2组胎膜组织中Ets-1和MMP-9阳性表达率。结果胎膜早破组胎膜组织Ets-1、MMP-9阳性表达率分别为66.7%、68.4%,明显高于对照组(20.0%、22.0%)(P<0.05)。结论 Ets-1和MMP-9在人类胎膜上均有表达,其高表达对预测胎膜早破发生有一定价值。Objective To explore the expression and effect of transcription factor Ets 1 and matrix metalloproteinase-9 （MMP-9） in premature rupture of membrane （PROM）. Methods Immunohistochemical SP method was used to detect the expressions of Ets 1 and MMP 9 in 57 patients with PROM （PROM group） and 50 normal full-term pregnant women （control group）. Results The positive expression rates of Ets-1 and MMP-9 were 66.7% and 68.4% in PROM group, significantly higher that those in control group （20. 0%, 22. 0%） （P〈0.05）. Conclusions Ets-1 and MMP-9 are expressed in human fetal membranes, and their high expressions help the prediction of PROM.

关 键 词：胎膜早破 转录因子ETS-1 基质金属蛋白酶9 

分 类 号：R714.433[医药卫生—妇产科学]