五味子乙素和右丙亚胺对阿霉素诱导心脏毒性的保护作用  

Prevention against and treatment of doxorubicin-induced acute cardiotoxicity by dexrazoxane and schisandrin B

作　　者：胡开永[1] 杨勇[2] 何莉华[2] 王多伟[2] 贾志荣[2] 李舒然[2] 田薇[2] 毛杰[2] 李娴静[2] 张伟[1] 

机构地区：[1]南通大学药学院,江苏南通226000 [2]中国药科大学,江苏南京211100

出　　处：《药学学报》2014年第7期1007-1012,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金重大研究计划资助项目(91129731)

摘　　要：比较五味子乙素(Sch B)与右丙亚胺(DEX)对阿霉素(DOX)诱导大鼠急性心脏毒性的保护作用。将SD大鼠随机分为6组,生理盐水组、阿霉素组、Sch B 80 mg·kg-1+阿霉素组、Sch B 40 mg·kg-1+阿霉素组、Sch B 20 mg·kg-1+阿霉素组和DEX+阿霉素组;大鼠尾静脉给予阿霉素(15 mg·kg-1)后诱导外周血中心肌酶升高、心肌组织中抗氧化损伤相关酶活力下降和心脏收缩与舒张功能障碍。而预先给予Sch B的大鼠都能够明显改善阿霉素诱导的上述症状,且保护效果好于DEX。结果提示,Sch B能预防阿霉素诱导大鼠的急性心脏毒性,其在临床上有潜在的应用价值。In this study, it is to compare the effectiveness of prevention against and treatment of doxorubicin（DOX） induced cardiotoxicity by dexrazoxane and schisandrin B（Sch B） in rats. Sprague-Dawley（SD） rats were randomly divided into the following 6 groups： normal saline group, DOX group, DOX＋DEX group, DOX＋Sch B（80 mg·kg-1） group, DOX＋Sch B（40 mg·kg-1） group and DOX＋Sch B（20 mg·kg-1） group. The results showed that Sch B could combat the increase of myocardial enzymes in peripheral blood, decrease of the enzyme activity of myocardial tissue antioxidant enzymes and disorders of systolic and diastolic function of heart in rats intravenously injected with doxorubicin（15 mg·kg-1）. Sch B was better than DEX in protecting rat against DOX-induced the symptoms. Sch B could protect rat against DOX-induced acute cardiomyopathy and has clinical potential applications.

关 键 词：五味子乙素 右丙亚胺 阿霉素 急性心脏毒性 

分 类 号：R965[医药卫生—药理学]