γ-分泌酶在皮肤病中的研究进展  

γ-Secretase in skin diseases

作　　者：肖学敏[1] 何艳艳[1] 张晓峰[1] 李诚让[1] 王宝玺[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042

出　　处：《国际皮肤性病学杂志》2014年第4期243-247,共5页International Journal of Dermatology and Venereology

基　　金：国家自然科学基金（81171522）

摘　　要：γ-分泌酶是一个包含四个疏水性亚基的跨膜蛋白水解酶,可以裂解包括β淀粉样前体蛋白、Notch受体等超过30种Ⅰ型跨膜蛋白.近年来,在多个家族性和散发性反常性痤疮的病例中发现了γ-分泌酶基因存在杂合突变.越来越多的文献表明,γ-分泌酶在维持皮肤正常生理功能和诸如炎症性皮肤病、皮肤肿瘤、感染性皮肤病、性病及结缔组织病等多种皮肤疾病中发挥重要作用.尽管目前尚无临床应用,γ-分泌酶的抑制剂和激活剂可能在未来为皮肤病的预防和治疗提供新的药物.γ-Secretase,a transmembrane protease complex composed of four hydrophobic subunits,is capable of cleaving more than 30 type 1 transmembrane proteins such as β-amyloid precursor protein and Notch receptors.Recently,heterozygous mutations in the γ-secretase gene have been reported in multiple cases of familial and sporadic acne inversa.More and more data have highlighted γ-secretase to have a significant role in the maintenance of physiological function of normal skin and in the development of multiple skin diseases such as inflammatory dermatoses,skin tumors,infectious dermatoses,sexually transmitted diseases and connective tissue diseases.Although there has been no clinical practice,γ-secretase inhibitors and activators may open a new door in the prevention and treatment of skin diseases in the future.

关 键 词：皮肤病学 Γ-分泌酶 反常性痤疮 Notch受体 

分 类 号：R751[医药卫生—皮肤病学与性病学]