紫外线对DNA甲基化影响的研究进展  

Effects of ultraviolet radiation on DNA methylation

作　　者：谷灿[1] 黄进华[2] 杨盛波[2] 

机构地区：[1]中南大学湘雅医学院,长沙410013 [2]中南大学湘雅三医院皮肤科

出　　处：《国际皮肤性病学杂志》2014年第4期267-269,共3页International Journal of Dermatology and Venereology

摘　　要：DNA甲基化是指在DNA甲基转移酶的催化下,胞嘧啶第5位碳原子共价键结合一个甲基基团,形成5-甲基胞嘧啶的化学修饰过程.DNA甲基化是主要的表观遗传学调控机制之一,在基因表达及突变等方面起重要作用.近年研究表明,光老化皮肤和皮肤癌中存在DNA甲基化的异常,其发生机制可能与DNA甲基转移酶的表达及活性下调、碱基/核苷酸剪切修复、生长停滞与DNA损伤诱导蛋白（Gadd45a）介导的DNA去甲基化等相关.DNA methylation,which refers to a chemical modification process in which a methyl group is covalendy binding to the 5-position of the cytosine ring in CpG dinucleotides to form 5-methylcytosine under the catalysis by DNA methyltransferases （DNMTs）,is a key epigenetic modification for gene regulation and mutation.Recent studies have shown that aberrant DNA methylation patterns exist in photoaged skin and ultraviolet radiation-induced skin tumors,which may be caused by decreased expression and activity of DNMT1,base excision repair and nucleotide excision repair,growth arrest,DNA-damage-inducible protein 45 alpha （Gadd45a）-mediated DNA demethylation,and so on.

关 键 词：紫外线 甲基化 细胞衰老 皮肤肿瘤 

分 类 号：R751[医药卫生—皮肤病学与性病学]