微小RNA在皮肤发育再生及创面愈合中的作用  

ROLE OF microRNA IN SKIN DEVELOPMENT AND WOUND HEALING

作　　者：宋志芳[1] 刘德伍[2] 

机构地区：[1]南昌大学第一附属医院心血管科,南昌330006 [2]南昌大学第一附属医院烧伤中心,南昌330006

出　　处：《中国修复重建外科杂志》2014年第7期913-918,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(30560058);江西省教育厅科研项目(GJJ12057)~~

摘　　要：目的综述微小RNA(microRNA,miRNA)在皮肤发育、再生与创面愈合各环节中的作用。方法查阅近年miRNA参与皮肤发育、再生及创面愈合方面的文献,并进行分析总结。结果 miRNA广泛参与了机体皮肤发育,包括表皮细胞的增殖、分化、衰老及毛囊的发育,尤其是miR-203被称为"皮肤特异性miRNA",可通过直接抑制p63基因表达而促进表皮分化。同时miRNA亦参与皮肤再生及创面愈合的各个阶段,miRNA的异常表达与创面畸形愈合密切相关。结论 miRNA在维持皮肤正常结构功能及创面再生修复过程中发挥重要作用,探讨其在皮肤创面愈合中的作用及调控机制并为治疗提供新靶点,具有潜在临床应用价值。Objective To review the role of microRNA（miRNA） in skin development and wound healing. Methods The recent literature about miRNA in skin development and wound healing was reviewed and analyzed. Results miRNA extensively involved in the development of the skin, including epidermal cell proliferation, differentiation, aging and hair follicle development; miR-203 known as the ＂skin-specific miRNA＂ can directly inhibit the expression of p63 and promote the differentiation of the epidermis. Meanwhile, miRNA also involved in various stages of skin regeneration and wound healing. Abnormal expression of miRNA is closely related with abnormal wound healing. Conclusion miRNA play an important role in maintaining normal skin physiology and skin regeneration. To explore their roles in the healing of skin wounds and their regulatory mechanism can provide a new target for the treatment, which has a potential value and broad prospects.

关 键 词：微小RNA 皮肤发育 皮肤再生 创面修复 

分 类 号：R641[医药卫生—外科学]