瑞格列奈联合二甲双胍治疗2型糖尿病临床疗效观察  

Clinical curative effect of repaglinide combined with metformin in the treatment of type 2 diabetes

作　　者：李玲[1] 任伶俐[1] 刘琳[1] 周广举[1] 彭乙华[1] 李娜[1] 蔡燕[2] 

机构地区：[1]川北医学院附属医院内分泌科,四川南充637000 [2]川北医学院附属医院检验科,四川南充637000

出　　处：《检验医学与临床》2014年第14期1895-1897,共3页Laboratory Medicine and Clinic

基　　金：四川省卫生厅基金资助项目(100165)

摘　　要：目的研究瑞格列奈联合二甲双胍治疗2型糖尿病的临床效果。方法选择2型糖尿病患者作为研究对象,分为瑞格列奈联合二甲双胍治疗的观察组和二甲双胍治疗的对照组,观察两组患者血糖水平、心功能以及下肢神经、运动功能。结果观察组舒张早期充盈峰速度(E峰)、E峰/舒张晚期充盈峰速度(A峰)值、射血分数(LVEF)、左心室舒张末期直径(LVEDD)以及行走距离、行走速度、运动神经的传导速度(MCV)、感觉神经的传导速度(SCV)均明显高于对照组;A峰值、下肢运动神经的潜伏期(LAT)均明显低于对照组;E峰、E峰/A峰、LVEF、LVEDD以及行走距离、行走速度、MCV、SCV均与糖化血红蛋白水平呈负相关,A峰值、LAT均与糖化血红蛋白水平呈正相关。结论瑞格列奈联合二甲双胍能够控制2型糖尿病患者血糖水平,进而起到改善心功能和下肢运动、神经功能的作用,具有积极的临床作用。Objective To study clinical effect of repaglinide combined with metformin in the treatment of type 2 diabetes .Methods A total of 400 patients with type 2 diabetic were divided into observation group ,treated with repaglinide combined with metformin ,and control group ,treated with metformin .Levels of blood sugar ,cardiac func-tion ,and lower limb nerve and motor function were observed .Results Early diastolic peak velocity （E peak） ,ratio of E and late diastolic peak velocity （A peak ,E/A） ,left ventricular ejection fraction （LVEF） ,left ventricular end dias-tolic diameter （LVEDD） ,walking distance ,walking speed ,motor nerve conduction velocity （MCV ） ,sensory nerves conduction velocity （SCV） were significantly higher than control group ,but A peak ,lower extremity motor nerve la-tency （LAT） were significantly lower .E peak ,E/A value ,LVEF ,LVEDD ,walking distance ,walking speed ,MCV and SCV were negatively correlated with glycosylated hemoglobin content ,and A peak and LAT were positively cor-related with glycosylated hemoglobin level .Conclusion Repaglinide combined with metformin could be efficient for controlling blood glucose level in patients with type 2 diabetic ,which could also improve cardiac function ,and lower limb nerve and motor function .

关 键 词：2型糖尿病 胰岛素 增敏剂 促分泌剂 

分 类 号：R587.1[医药卫生—内分泌]