灯盏花素鼻用微乳凝胶剂的鼻纤毛毒性研究  

A study on the ciliotoxicity of breviscapine microemulsion-based nasal gels

作　　者：姚娜[1] 黄庆德[1] 胡建萍[1] 陈雪[1] 

机构地区：[1]福建中医药大学药学院,福建福州350122

出　　处：《中医临床研究》2014年第16期19-20,共2页Clinical Journal Of Chinese Medicine

基　　金：福建省科技计划重点项目(2012Y0042);福建省教育厅A类科技项目(JA11130);福建省科技计划项目(2010Y2004)

摘　　要：目的:研究灯盏花素鼻用微乳凝胶剂对鼻腔纤毛运动的影响。方法:采用在体蟾蜍上颚模型法,给予自制的灯盏花素鼻用微乳凝胶剂,记录纤毛持续摆动时间,并于显微镜下观察纤毛形态学改变。结果:灯盏花素鼻用微乳凝胶剂对鼻腔纤毛运动无明显影响,相对于NS,纤毛持续摆动时间的相对百分率为93.8%。结论:灯盏花素鼻用微乳凝胶剂无明显鼻腔纤毛毒性,可以用于鼻腔给药。Objective： To study the ciliotoxicity of breviscapine microemulsion-based nasal gels. Methods： The lasting time of ciliary movement was determined and the ciliary morphology was observed with microscope after administration in situ toad palate mode. Results：Breviscapine microemulsion-based nasal gels had no significant effect on ciliary movement. The relative percentage of the lasting time of ciliary movement with physiological was 93.8%. Conclusion：In this study the breviscapine microemulsion-basednasal gels has no significant ciliotoxicity and it can be used for intranasal administration.

关 键 词：灯盏花素 微乳凝胶剂 鼻用 纤毛毒性 

分 类 号：R289[医药卫生—方剂学]