强的松对紫癜性肾炎患儿尿转化生长因子-β1的影响  

Effect of prednisone on urinary transforming growth factor-beta 1 levels in children with HenochSchonlein purpura nephritis

作　　者：谢云惠[1] 盛晓翠[1] 

机构地区：[1]云南省第二人民医院儿科,昆明650021

出　　处：《中国实用医刊》2014年第15期58-59,共2页Chinese Journal of Practical Medicine

摘　　要：目的探讨过敏性紫癜性肾炎（HSPN）患儿尿转化生长因子-β1（TGF-β1）变化及强的松对其的影响。方法用ELISA法检测56例HSPN患儿尿TGF-β1水平，观察强的松治疗对患儿TGF-β1的影响并进行临床分析。结果HSPN患儿尿TGF-β1与正常对照组比较差异有统计学意义（P〈0．01）；强的松治疗8周尿蛋白转阴患儿治疗后尿TGF-β1显著下降（P〈0．01），而未转阴患儿治疗前后比较差异无统计学意义。结论HSPN患儿尿TGF-β1显著升高，说明TGF-β1参与了患儿的免疫病理过程，强的松降低患儿尿TGF-β1可能与蛋白尿减少有关。Objective To investigate effect of prednisone on urinary transforming growth factorbeta 1 （ TGF-β1） levels in children with Henoch-Schonlein purpura nephritis （ HSPN ）. Methods ELISA was used to measure the levels of urinary TGF-β1 in 56 children with HSPN and 31 controls. And the effects of prednisone on children with HSPN with prednisone was analyzed. Results Urinary TGF-β1 levels in children with HSPN were significantly higher than those in controls, and the urinary TGF-β1 levels in children converted to negative urine protein were significantly decreased after treated with prednisone for 8 weeks, and there was no significant difference in children still with urinary protein. Conclusions Urinary TGF-β1 level is increased in children with HSPN, suggesting that reduced urinary TGF-β1 level in children by prednisone may be associated with the reduced proteinuria level.

关 键 词：转化生长因子-Β1 过敏性紫癜性肾炎 

分 类 号：R726.9[医药卫生—儿科]