不同促排卵方案对多囊卵巢综合征患者IVF-ET结局的影响  

Comparison of IVF outcomes of different gonadotroph in stimulation protocol for patients with polycystic ovary syndrome( PCOS)

作　　者：张宜瑄[1] 张少娣[1] 耿嘉瑄[1] 李萌[1] 张翠莲[1] 

机构地区：[1]河南省人民医院生殖中心,郑州450000

出　　处：《医药论坛杂志》2014年第6期22-24,共3页Journal of Medical Forum

摘　　要：目的分析不同促排卵方案对多囊卵巢综合征(PCOS)患者体外受精-胚胎移植(IVF-ET)周期治疗结果的影响。方法回顾性分析2012年1月至2013年1月行IVF长方案助孕治疗的PCOS患者共127取卵周期,按Gn用量分为A组:恒量方案组(共89周期)和B组:剂量递增方案组(共38周期),对治疗中及治疗结局相关因素进行比较分析。结果恒量方案组Gn用量及Gn天数显著低于递增方案组,HCG日>19mm卵泡数、穿刺卵泡数、获卵总数、周期取消率均显著高于递增方案组,两组内复融周期妊娠率比新鲜周期均显著增加;其余各项差异无统计学意义。结论恒量方案组可减少用药量,提高获卵数。PCOS患者可考虑新鲜周期全胚冷冻,复融周期移植方案降低OHSS发生率,提高妊娠率。Objective To evaluate the clinical outcomes of different gonadotroph in stimulation protocol for polycystic ovary syndrome （PCOS） patients in vitro fertilization （IVF） cycles. Methods A retrospective analysis of 127 IVF cycles of PCOS patients in our center with long agonist protocol from January 2012 to January 2013. They were divided by the dose of FSH ; Group A ： constant protocol（89 cycles） and group B ： incremental protocol （38 cycles） and compared the treatment outcomes between the two groups. Results The total dose of FSH and the days of FSH under constant protocol wore significantly lower than incremental protocol. 〉 19mm follicles on hCG administration day, No. of punctured follicles, total No. of oocytes retrieved, cycle cancellation rate under constant protocol were significantly higher than those the incremental group. Pregnancy rates were significantly increased in the frozen embryos cycles than the fresh embryos cycles in the two groups. The rest of the other factors were not significantly different between the two groups. Conclusion Constant protocol can reduce the total dose of FSH, and increase the number of oocytes. PCOS patients may consider the whole embryos frozen to reduce the incidence of OHSS and improve pregnancy rates.

关 键 词：多囊卵巢综合症(PCOS) 试管婴儿(IVF) 长方案 促排卵 

分 类 号：R711.75[医药卫生—妇产科学]