冠心病介入术患者血管内皮依赖性舒张功能与血小板L-精氨酸/一氧化氮通路的关系  

The relation between endothelium-dependent vasodilator function and platelet L-arginine/nitric oxide pathway in patients with percutaneous coronary intervention

作　　者：问慧娟[1] 李亚芹[2] 崔玉英[1] 李玉巧[1] 

机构地区：[1]河北大学基础医学院生理系,河北保定071000 [2]河北大学附属医院心内科,河北保定071000

出　　处：《重庆医学》2014年第20期2545-2547,共3页Chongqing medicine

基　　金：河北省科学技术研究与发展计划项目(11276103D-7);河北省卫生厅重点科技研究计划项目(20100141);河北大学医学学科专项资金建设项目(2013A2001)

摘　　要：目的探讨冠心病患者经皮冠状动脉介入治疗(PCI)手术前、后血小板L-精氨酸(L-Arg)/一氧化氮合成酶(NOS)/一氧化氮(NO)通路和血管内皮依赖性舒张功能(FMD)的变化和关系。方法对照组17例,为健康体检者;PCI组20例,为接受PCI成功的冠心病患者。分别于对照组体检当天及PCI组术前、术后即刻、术后24h和术后72h,检测肱动脉FMD、血小板孵育液亚硝酸盐(NO2-)水平、NOS活性及L-Arg转运量,分析FMD与血小板NO、NOS和L-Arg转运量间的关系。结果 PCI组术前FMD和血小板NO2-水平、NOS活性、L-Arg转运量较对照组显著降低(P<0.01);术后即刻进一步下降(P<0.01),术后24h逐渐恢复,术后72hFMD、NO2-、NOS、L-Arg转运均恢复到术前水平(P>0.05);PCI手术前、后FMD与血小板NO2-、NOS、LArg转运改变均呈显著正相关(P<0.01)。结论检测血小板L-Arg/NO通路可反映PCI血管内皮功能的改变。Objective To investigate alteration and cross link of the vascular endothelium dependent diastolic function （FMD） and platelet endogenous L-arginine/NOS/NO pathway before and after percutaneous coronary intervention （PCI） .Methods The study included two groups ：normal control group（17 cases） and PCI group（20 cases） .FMD of brachial artery and NO production , NOS activity ,L-arginine transport in platelets were examined respectively before ,immediately ,24 h and 72 h after PCI and the rela-tionships between them would subsequently be analysed .Results The preoperative FMD ,content of NO2 - ,NOS activity and L-ar-ginine of PCI group significantly decreased than the normal control group （P〈0 .01） ,and further decreased in the immediate post-operative（P〈0 .01） .Gradually recovered 24 h after surgery ,72 h after surgery ,the FMD ,NO2 - ,L-arginine transport ,NOS activity restored to the preoperative level （P〉0 .05） .The analysis showed the obvious positive correlation between FMD and content of NO2 - or NOS activity ,or L-arginine transport of platelet ,respectively（P〈0 .01） .Conclusion The pathway of platelet L-arginine/NOS/NO was significantly positively correlated with FMD and the detection of platelet L-arginine/NOS/NO can reflect the changes of vascular endothelial function with PCI .

关 键 词：一氧化氮 经皮冠状动脉介入术 内皮依赖性舒血管功能 一氧化氮合酶 L-精氨酸转运 

分 类 号：R541.4[医药卫生—心血管疾病]