两种HAART方案对HIV/AIDS患者血脂的影响  

The impact to blood lipid in patients with HIV/AIDS using two different HAART regimens

作　　者：李虹[1] 陈媛媛[1] 何云[1] 李超锋[1] 刘春礼[1] 孙燕[1] 赵清霞[1] 

机构地区：[1]河南省郑州市第六人民医院感染科,450015

出　　处：《重庆医学》2014年第20期2574-2576,共3页Chongqing medicine

基　　金：郑州市科技发展计划课题(112PPTSF303-3)

摘　　要：目的观察两种高效抗逆转录病毒治疗(HAART)方案应用48周对HIV/AIDS患者血脂的影响。方法将102例HIV/AIDS患者根据不同的HAART方案分为司他夫定(D4T)组[D4T联合拉米夫定(3TC)及奈韦拉平(NVP)治疗]和齐多夫定(AZT)组(AZT联合3TC及NVP治疗)。检测基线及HAART后24、48周时的三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)水平。结果配对t检验分析,D4T组患者24周TG、TC和LDL-C均显著升高(P<0.05),48周TC仍持续升高(P<0.05);AZT组24周TC和TG显著升高(P<0.05)。独立t检验分析,24、48周两组间比较血脂各项指标差异无统计学意义(P>0.05)。结论包含D4T和AZT的HAART方案均可导致HIV/AIDS患者血脂异常,主要是TG和TC升高,均以边缘升高为主。应用包含D4T的方案的HIV/AIDS患者TG和TC升高较早,并且TC升高后持续保持在较高的水平。Objective To understand the impact to blood lipid in patients with HIV/AIDS using different HAART regimens . Methods According to HAART regimens ,102 HIV/AIDS patients were divided into two groups ：D4T group（D4T＋3TC＋NVP） and AZT group（AZT＋3TC＋ NVP） .Blood lipids（TG ,TC ,LDL-C and HDL-C）at baseline ,24 weeks and 48 weeks after HAART were detected .Results Compared with paired t test ,TG ,TC and LDL-C at 24 weeks follow-up of the patients in D4T group were significantly higher than at baseline（P〈0 .05） ,and TC at 48 weeks follow-up were still higher than at baseline（P〈0 .05） .TG and TC at 24 weeks follow-up of patients in AZT group were significantly higher than at baseline（P〈0 .05） .There were no significant difference at blood lipid between the two groups（P〉0 .05） .Conclusion There are dyslipidemia of the patients with HIV/AIDS u-sing D4T-based and AZT-based regimens ,and the dyslipidemia are increase of TC and TG ,these increase is border higher .TG and TC at 24 weeks follow-up of the HIV/AIDS patients using D4T-based regimen are increased early ,and TC are still at higher level .

关 键 词：抗逆转录病毒治疗 高效 获得性免疫缺陷综合征 血脂 

分 类 号：R512.91[医药卫生—内科学]