菝葜不同浓度乙醇提取物的抗炎活性筛选  

Screening of the Different Concentrations of Ethanol Extracts from Smilax China for Its Antiinflammatory Activity

作　　者：罗艳琴[1] 马云[1] 宋路瑶[1] 秦飞[1] 范银洲[2] 侯连兵[1] 

机构地区：[1]南方医科大学南方医院药学部,广州510515 [2]南方医科大学药学院,广州510515

出　　处：《医药导报》2014年第7期858-862,共5页Herald of Medicine

基　　金：广东省医院药学研究基金(奥赛康基金)(2014A14)

摘　　要：目的研究菝葜不同浓度乙醇提取物治疗小鼠耳肿胀模型和大鼠棉球肉芽肿模型的药理作用,为确定菝葜最佳提取工艺提供参考。方法采用不同浓度乙醇制备菝葜提取物,观察其对二甲苯致小鼠耳肿胀模型和大鼠棉球肉芽增生的影响。结果与模型对照组比较,高、中、低剂量菝葜70%乙醇提取物对小鼠耳肿胀度有显著的抑制作用(t=2.58,P<0.05;t=2.28,P<0.05;t=2.17,P<0.05),可明显降低大鼠棉球肉芽肿增生(t=5.28,P<0.01;t=5.24,P<0.01;t=5.17,P<0.01)。结论小鼠耳肿胀和大鼠棉球肉芽肿两种模型证实,菝葜70%乙醇提取物各剂量组的抗炎活性作用最好。Objective To study the effects of the different concentrations of ethanol extracts of Smilax China on ear edema in mice and granuloma in rats,and to provide an evidence for optimizing the extraction process. Methods Effects of different concentrations of ethanol extracts of Smilax China on the xylene-induced ear edema in mice and the cotton ball-induced granuloma hyperplasia in rats were tested . Results Compared with the model controls,70% ethanol extracts of Smilax China at high,medium and low doses significantly inhibited ear edema in mice （t=2. 58,P〈0. 05;t=2. 28,P〈0. 05;t=2. 17,P〈0. 05） and reduced the granuloma hyperplasia in rats（t=5. 28,P〈0. 01;t=5. 24,P〈0. 01;t=5. 17,P〈0. 01）. Conclusion The 70% ethanol extracts of Smilax China at three doses present the most active antiinflammatory effect,confirmed in both mice ear edema and rats granuloma models.

关 键 词：菝葜 乙醇提取物 肿胀 耳 肉芽肿 

分 类 号：R282.71[医药卫生—中药学] R285.5[医药卫生—中医学]