加味二仙颗粒治疗绝经后骨质疏松症的临床疗效观察  

Clinical Efficacy of Jiaweierxian Granule Treatment on Postmenopausal Women with Osteoporosis

作　　者：吴峰[1] 蔡立雄[1] 陈健荣[1] 王刚[1] 

机构地区：[1]佛山市中医院骨科,广东佛山528000

出　　处：《赣南医学院学报》2014年第3期360-363,380,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：2011年广东省中医药局立项课题(20111055)

摘　　要：目的:探讨加味二仙颗粒治疗绝经后骨质疏松症的临床疗效。方法:97例符合纳入标准并完成随访的绝经后妇女骨质疏松症患者随机分为试验组与对照组,试验组口服加味二仙颗粒,对照组口服仙灵骨葆胶囊,采用VAS评分、骨密度(BMD)、骨转换标记物:BALP、DPD/Cr、BGP、CTX-Ⅰ及疗效评定综合比较两组治疗前后疗效。结果:在治疗后12周实验组及对照组VAS评分均明显改善,实验组改善更明显,BMD在治疗后48周才出现明显改善,但实验组与对照组比较无明显统计学差异,治疗组与对照组在治疗12周后BALP、DPD/Cr、BGP、CTX-Ⅰ值出现明显下降,但实验组及对照组差别不明显,治疗72周后试验组治疗有效率85.7%,对照组87.5%,差异无统计学意义。结论:加味二仙颗粒治疗绝经后骨质疏松症的临床疗效确切,用于治疗监测时,骨转换标志物改变较骨密度改变出现更早。Objective： To investigate the clinical efficacy of jiaweierxian granules treatment on postmenopausal women with osteoporosis. Methods： From January,2011 to October,2012,ninety-seven postmenopausal women with osteoporosis were enrolled in a prospective study and assigned to one of two groups. The first group received an treatment with jiaweierxian granules while the second group as the control group prescript for use of Xianlinggubao capsules. All patients were prospectively followed,and clinical outcomes were evaluated with Visual Analog Scale,BMD,Bone turnover markers of BALP、DPD /Cr、BGP 、CTX-Ⅰ,comprehensive evaluation of efficacy for osteoporosis. Results： Visual Analog Scale were significantly improved in two groups after treatment for 8 weeks,the improvement were more evident in the patients in treatment of jiaweierxian granules than the control group. BMD was significantly improved only after 48 weeks treatment in two groups. However,significant difference appeared in Bone turnover markers of BALP、DPD /Cr、BGP 、CTX-Ⅰ at 12weeks follow-up in two groups,but there was no difference between two groups in BMD and Bone turnover markers of BALP、DPD /Cr、BGP 、CTX-Ⅰ. At final follow-up（ 72weeks） the rate important improvement used comprehensive evaluation of efficacy for osteoporosis were 85. 7% and 87. 5% respectively in two groups and had no difference statistically.Conclusion： Jiaweierxian granules treatment on postmenopausal women with osteoporosis is effective,in monitoring the efficacy of treatment on postmenopausal women with osteoporosis,the changes of bone turnover markers were earlier than that of BMD.

关 键 词：加味二仙颗粒 绝经后骨质疏松症 治疗 

分 类 号：R681.4[医药卫生—骨科学]