Protective effect of Nigella sativa oil against binge ethanolinduced oxidative stress and liver injury in rats  

作　　者：Seval Develi Betül Evran Esra Betül Kalaz Necla Koak-Toker Gül zdemirler Erata 

机构地区：[1]Department of Biochemistry, Istanbul Medical Faculty, Istanbul University,apa, 34093, Istanbul, Turkey

出　　处：《Chinese Journal of Natural Medicines》2014年第7期495-499,共5页中国天然药物（英文版）

基　　金：supported by the Research Fund of Istanbul University(No.6101)

摘　　要：AIM: Nigella sativa L.(Ranunculaceae) is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect of Nigella sativa oil(NSO) pretreatment on ethanol-induced hepatotoxicity in rats. METHOD: Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL·kg-1, orally for 3 weeks, followed by oral ethanol(EtOH) administration(5 g·kg-1) every 12 h three times(binge model). RESULTS: Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde(MDA) levels. It decreased hepatic glutathione(GSH) levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO(5.0 mL·kg-1) pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings. CONCLUSION: NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol administration.AIM： Nigella sativa L. （Ranunculaceae） is considered as a therapeutic plant-based medicine for liver damage. In this study, the aim was to study the effect ofNigella sativa oil （NSO） pretreatment on ethanol-induced hepatotoxicity in rats. METHOD： Rats were given Nigella sativa oil at doses of 2.5 and 5.0 mL.kg-1, orally for 3 weeks, followed by oral ethanol （EtOH） administration （5 g.kg-1） every 12 h three times （binge model）. RESULTS： Binge ethanol application caused significant increases in plasma transaminase activities and hepatic triglyceride and malondialdehyde （MDA） levels. It decreased hepatic glutathione （GSH） levels, but did not change vitamins E and vitamin C levels and antioxidant enzyme activities. NSO （5.0 mL.kg-1） pretreatment significantly decreased plasma transaminase activities, hepatic MDA, and triglyceride levels together with amelioration in hepatic histopathological findings. CONCLUSION： NSO pretreatment may be effective in protecting oxidative stress-induced hepatotoxicity after ethanol ad ministration.

关 键 词：Nigella sativa Binge ethanol Oxidative stress LIVER RATS 

分 类 号：R965[医药卫生—药理学]