血小板计数对判断肺结核病情的价值探讨  

Clinical value of peripheral platelet count in assessing active pulmonary tuberculosis

作　　者：尹洪云[1] 冯永红 邹丹凤[1] 肖和平[1] 

机构地区：[1]同济大学附属上海市肺科医院结核病诊疗中心,上海200433 [2]上海市结核病(肺)重点实验室

出　　处：《中国感染与化疗杂志》2014年第4期276-279,共4页Chinese Journal of Infection and Chemotherapy

基　　金：国家自然科学基金(30872364;81172806)

摘　　要：目的了解外周血小板计数增高对结核病患者病情的诊治价值。方法选择2012年1—6月住院初治肺结核进展期80例(进展期组)、治疗后好转期43例(好转期组)及同期健康体检者89名(对照组)。采用血常规细胞计数仪检测外周血白细胞、血小板计数,中性粒细胞比值;同日送检血红细胞沉降率(ESR)及C反应蛋白(CRP)。SPSS13.0统计软件处理数据。结果进展期组ESR及CRP分别明显高于好转期组(P=0.006 5,P=0.007 3);进展期组血小板计数高于正常参考值上限者占41.94%,均值亦明显高于好转组及对照者(分别为P=0.001 4,P=0.0000);且血小板计数分别与ESR及CRP呈正相关。而白细胞计数及中性粒细胞比值与对照组比较差异无统计学意义(P>0.05)。结论结核病患者外周血血小板计数升高,对判断病情的活动性及治疗效果具有一定参考价值。Objective To understand the role of increasing peripheral blood platelet count in the diagnosis and prognosis of patients with active pulmonary tuberculosis. Methods This analysis included 80 inpatients with active pulmonary tuberculosis evidenced by positive sputum smear, 43 patients in recovery and 89 healthy controls during the period from January to June in 2012. Peripheral white blood cell, platelet count, and neutrophil percentage were assayed. Erythroeyte sedimentation rate （ESR） and serum C-reactive protein （CRP） were measured and compared. The data were analyzed by using SPSS 13. 0 software. Results ESR and CRP values were significantly higher in the patients with active pulmonary tuberculosis than in the patients in recovery （P = 0. 006 5 and P = 0. 007 3, respectively）. The peripheral blood platelet count exceeded normal range in 41.94% of the patients with active pulmonary tuberculosis, which was significantly higher than that in the patients in recovery （P= 0. 001 4） and controls （P= 0. 000 0）. Platelet count was positively correlated with CPR （r= 0. 515, P〈0. 000 1） and ESR （r= 0. 398, P〈0. 001 ） value. However, peripheral white cell count and neutrophil count were not different from the corresponding values of controls. Conclusions Increasing peripheral platelet count may play a role in assessment of tuberculosis disease activity and the effect of antktuberculosis treatment.

关 键 词：肺结核 血小板 白细胞 红细胞沉降率 C反应蛋白 

分 类 号：R521[医药卫生—内科学]