中国成人万古霉素给药剂量的商榷  

Discussion of vancomycin dosage in Chinese adult patients

作　　者：方洁[1] 何乐[1] 程齐俭[2] 

机构地区：[1]上海交通大学医学院附属瑞金医院药剂科,上海200025 [2]上海交通大学医学院附属瑞金医院呼吸科,上海200025

出　　处：《中国感染与化疗杂志》2014年第4期291-294,共4页Chinese Journal of Infection and Chemotherapy

摘　　要：目的探讨中国成人万古霉素每日2g给药方案，能否达到10--20mg／L的目标血药浓度。方法回顾性分析交通大学医学院附属瑞金医院2011年9月至2012年12月收治的使用万古霉素且进行血药浓度监测的122例住院患者临床资料，分析给药剂量、年龄、性别、体重、合并用药等与血药谷浓度的相关性。结果按说明书给药的患者中，62．1％血药谷浓度低于目标血药谷浓度。年龄是患者用药后血药浓度是否能够达到目标值的独立危险因素，对于符合说明书剂量给药的患者，年龄〈60岁者中70．0％低于目标血药浓度；年龄≥60岁者中，62．5％达到或高于目标血药浓度。结论临床医师和药师需审慎地评估患者的给药剂量，尤其应该考虑年龄的独立影响因素。Objective To study whether vancomycin dosage 2 g daily in Chinese adult patients would achieve the target serum trough concentration of 10-20 mg/L. Methods The data of 122 adult inpatients under therapeutic drug monitoring while receiving vancomycin were collected from September 2011 to December 2012. The correlation between vancomycin trough concentration and dosage, age, sex, body weight, concomitant medications were analyzed retrospectively. Results Vancomycin trough concentration was below the target concentration in 62. 1% of the included patients. Age is an independent risk factor for attainting target concentration. Serum concentration was below target concentration in 70.0 % of the patients below 60 years of age. Serum concentration was above target concentration in 62. 5% of the patients above 60 years of age. Conclusions Clinicians and pharmacists should assess the dosage regimen of vancomycin cautiously, and age should be considered especially as an independent risk factor.

关 键 词：万古霉素 给药剂量 血药谷浓度 

分 类 号：R978[医药卫生—药品]