非粒细胞缺乏肺曲霉病患者血清Dectin-1的检测  

Serum Dectin-1 in non-agranulocytic patients with pulmonary aspergillosis

作　　者：徐小勇[1] 陈菲[1] 高卫卫[1] 孙禾[1] 李培[1] 施毅[1] 

机构地区：[1]南京军区南京总医院呼吸与危重症医学科,南京210002

出　　处：《中国感染与化疗杂志》2014年第4期301-304,共4页Chinese Journal of Infection and Chemotherapy

摘　　要：目的探讨非粒细胞缺乏肺曲霉病患者血清Dectin-1检测的临床意义。方法收集非粒细胞缺乏的曲霉病患者22例(肺曲霉病组),健康体检者54例(对照组),留取血清,ELISA方法检测两组血清Dectin-1水平。分析Dectin-1水平与血清1,3-D葡聚糖抗原检测(G试验)、半乳甘露聚糖抗原检测(GM试验)和血白细胞计数的关系。结果肺曲霉病组血清Dectin-1水平为(427.2±42.6)pg/mL,对照组为(280.8±39.4)pg/mL,差异有统计学意义(P<0.05);Dectin-1水平与血白细胞计数、G试验、GM试验无相关性。结论在非粒细胞缺乏曲霉病患者血清中,Dectin-1水平明显增高,提示Dectin-1是重要的抗曲霉免疫分子。Objective To explore the clinical implication of serum Dectin-1 level in the non-agranulocytie patients with pulmonary aspergillosis. Methods Serum specimen were collected from the non-agranulocytic patients with pulmonary aspergillosis to determine the serum level of Dectin-1 with ELISA. The relationship between serum Dectin-1 level, the results of G test and galactomannan （GM） test of Aspergillus, and white blood cell count was analyzed. Results The serum Dectin-1 level was （427.2±42.6） pg/mL in the patients with Aspergillus infection, and （280. 8±39. 4） pg/mL in the control patients （P〈0. 05）. Dectin-1 level was not correlated to white blood cell count, or the result of G test, or GM test. Conclusions Serum Dectin-1 level increases significantly in the non-agranulocytic patients with pulmonary aspergillosis, suggesting that Dectin-1 is an important anti-Aspergillus immune molecule.

关 键 词：肺曲霉病 非粒细胞缺乏 DECTIN-1 免疫 

分 类 号：R519[医药卫生—内科学]