对硝基溴苄的合成工艺研究  

Study on the Synthetic Technology of 4 - Nitrobenzyl Bromide

作　　者：叶彬彬 王玲燕 谢菊冲 何文杰 徐丹萍 

机构地区：[1]浙江海翔药业股份有限公司研究院,浙江台州318000

出　　处：《广州化工》2014年第13期85-86,共2页GuangZhou Chemical Industry

摘　　要：以对硝基甲苯作为原料,针对传统的溴素制备氢溴酸上溴工艺,改进溴化剂,引入N-溴代丁二酰亚胺(NBS)作为溴化剂,偶氮二异丁腈(AIBN)作为引发剂,二氯甲烷作为最佳反应溶剂,50℃反应8 h,反应收率≥85%。该工艺路线具有生产成本低、操作简便、反应时间短、适合工业化生产以及符合环保要求等特点。A new method of preparation 4 -nitrobenzyl bromide was developed using p -nitrotoluene as raw material, NBS as bromination agent and AIBN as initiator , with the optimum solvent methylene chloride , reaction temperature 50 ℃, reaction time 8 h, and the yield was up to 85%.The method of the basis of traditional process of bromine bromine preparation hydrobromide improved agent bromide.This process route had the characteristics of a low production cost , simple operation , short reaction time , easy industrial production and environmentally friendly.

关 键 词：对硝基溴苄 溴化 合成 对硝基甲苯 

分 类 号：TQ612.1[化学工程—精细化工]