人源甲型H1N1流感HA基因进化特征分析  

Human A(H1N1)influenza HA gene evolution characteristic analysis

作　　者：金梦哲 綦朝晖[1] 李素丽[1] 

机构地区：[1]石家庄铁道大学信息科学与技术学院,河北石家庄050043

出　　处：《河北省科学院学报》2014年第2期83-89,共7页Journal of The Hebei Academy of Sciences

基　　金：河北省自然科学基金资助项目(F2012210017)

摘　　要：为了探究2009年3月至8月流感大爆发期间的人源甲型H1N1流感病毒的进化特征,提出了一种图形化表达病毒序列的方法,该方法将甲型H1N1流感病毒HA基因的符号序列数字化表达后,利用主成分分析(PCA)将高维数值序列的维度大幅度降低为二维,将低维的数值序列图形化表达在平面和空间中。在序列的图形化表达基础上,对2009年3月到8月收集的三千多个流感病毒样本做了新旧病毒的区分,筛选出了新型病毒菌株,并根据图形探究了甲型H1N1流感病毒在时间序列上的进化特征。To explore the evolution characteristics of human influenza A（H1N1）virus during the the influenza pandemic from March 2009to August,a method for virus sequence graphical presentation is proposed.The method substantially reduces the dimension of high-dimensional numerical sequence to two after digitization of the original symbol sequence by using principal component analysis（PCA）.The low-dimensional sequence is graphically represented in the plane and space.On the basis of the graphical representation,the paper makes a distinction between the old and the new type of viruses among the samples of more than three thousand influenza virus collected in March 2009to August,and new virus strains are filtered out.According to the figure the evolutionary traits of the H1N1flu virus in time series are screened out.

关 键 词：甲型H1N1流感病毒 主成分分析 降维 图形化表达 

分 类 号：R373.1[医药卫生—病原生物学]