癌基因Emi1在乳腺癌组织中的表达及其对预后的影响  

Expression and clinicopathological significance of Emi1 in breast carcinoma

作　　者：刘小兵[1] 倪启超[1] 盛陈毅[1] 马菁[1] 王庆庆[1] 

机构地区：[1]南通大学附属医院普外科, 江苏南通226001

出　　处：《中华医学杂志》2014年第26期2008-2012,共5页National Medical Journal of China

基　　金：国家自然科学基金（30972937）;江苏省卫生厅基金（H201017）

摘　　要：目的：通过检测新发现的癌基因Emi1在乳腺癌中的表达情况，探讨其与乳腺癌癌变的关系及其预后意义。方法收集93例乳腺癌及癌旁组织，采用免疫组织化学法检测Emi1在这些组织中的表达，并与增殖细胞核抗原（Ki-67）的表达相比较。结合临床病理资料分析该分子在乳腺癌中的临床意义。结果 Emi1在乳腺癌组织中高表达，且Emi1的表达与乳腺癌的组织分化程度（ P＝0.002），淋巴结转移（P＝0.017）及ER（P＝0.038）有关，但与患者的年龄、肿瘤大小、组织学类型、孕激素受体（PR）、人表皮生长因子受体2（HER-2）、P53等临床病理参数无关。而乳腺癌中Ki-67的表达与Emi1表达变化结果相似。相关性分析表明乳腺癌组织中Emi1的表达与Ki-67的表达呈明显正相关（ r^2＝0.454，P＝0.002）。多因素分析发现：组织分化程度、淋巴结状态、Ki-67和Emi1的表达与患者的总生存率均有明显的相关性。结论 Emi1是一个新的乳腺癌相关基因，很可能在乳腺癌的浸润转移中起重要作用，是乳腺癌患者的一个重要预后指标，可作为潜在的治疗靶点。Objective To examine the expression and prognostic value of novel oncogene Emi 1 in breast cancer.Methods Immunohistochemical analysis was performed for 93 human breast carcinoma samples and adjacent normal tissues for detecting the expression of Emi 1 and cell proliferative factor Ki-67.Then the data were correlated with clinicopathological features.Results Emi1 was highly expressed in breast carcinoma tissues compared with adjacent normal tissues.Emi1 expression was significantly associated with histological grade （ P=0.002 ） , axillary lymph node status （ P =0.017 ） and ER status （ P =0.038 ）.However , there was no correlation between Emi 1 expression and other factors such as age , tumor size , histology, PR status, HER-2 or P53.Meanwhile similar results were obtained for Ki-67 expression.A marked correlation also existed between Emi 1 and Ki-67 expression （Spearman′s r2 =0.454, P=0.002）. Conclusion As a novel breast cancer associated gene , Emil plays an important role in evaluating invasion and metastatic potentiality in breast cancer.And it is also an important prognostic predictor of breast cancer so as to become a potential therapeutic target for breast cancer.

关 键 词：乳腺肿瘤 Emi1 基因表达调控 肿瘤 预后 

分 类 号：R737.9[医药卫生—肿瘤]