Characterization of cocrystals formed by grinding amino acids through terahertz time-domain spectroscopy  

作　　者：Xiaoyan Zhao Haixia Su Zhaohui Zhang Zhi Li Han Zhang Tianyao Zhang 

机构地区：[1]Department of Instrumentation Science, School of Automation and Electrical Engineering, University of Science and Technology Beijing

出　　处：《Chinese Science Bulletin》2014年第24期2987-2993,共7页

基　　金：supported by the National Natural Science Foundation of China (61302007 and 60977065);the Fundamental Research Funds for the Central Universities (FRF-SD12-016A)

摘　　要：In this paper,we used terahertz time-domain spectroscopy(THz-TDS)over a range of 0.3–2.5 THz to investigate the formation of solid-state cocrystals of amino acids,formed by grinding mixtures of two different kinds of amino acids.For comparison,we prepared dual-layer samples,combined by pressing two single-component pellets together without grinding.In the ground-mixture samples,some extra absorption peaks appeared,different from the characteristic peaks of the pure components,but these peaks did not appear in the dual-layer samples.Thus,these extra absorption peaks in the THz range are unique features of cocrystals.From our results,we believe that THz-TDS is a promising technique to characterize cocrystals.In this paper, we used terahertz time-domain spectroscopy （THz-TDS） over a range of 0.3-2.5 THz to investigate the formation of solid-state cocrystals of amino acids, formed by grinding mixtures of two different kinds of amino acids. For comparison, we prepared dual-layer samples, combined by pressing two single-component pellets together without grinding. In the ground-mixture samples, some extra absorption peaks appeared, different from the characteristic peaks of the pure components, but these peaks did not appear in the dual-layer samples. Thus, these extra absorption peaks in the THz range are unique features of cocrystals. From our results, we believe that THz-TDS is a promising technique to characterize cocrystals.

关 键 词：太赫兹时域光谱 氨基酸 结晶物 表征 太赫波 磨削 混合物 共结晶 

分 类 号：O629.7[理学—有机化学]