Toll样受体信号转导与中枢神经系统疾病  

Signal Transduction of Toll-like Receptors and the Central Nervous System Disease

作　　者：武海霞[1] 吴志刚[1] 刘红彬[1] 沈丽霞[1] 

机构地区：[1]河北北方学院药学系

出　　处：《神经药理学报》2012年第4期32-39,共8页Acta Neuropharmacologica

基　　金：河北省自然科学基金资助项目(No.H2012405016);河北省教育厅资助项目(No.Z2013069);河北北方学院创新人才培育基金(No.CXRC1325);2013年度河北北方学院校级重大项目(No.ZD201310)

摘　　要：Toll样受体(toll-like receptors,TLRs)是一类模式识别受体,在药物研究领域受到广泛关注,TLRs能特异地识别病原相关的分子模式,在激活天然免疫和调节获得性免疫中发挥重要作用。近年来,TLRs信号转导在中枢神经系统疾病方面的研究进展迅速,该文对TLRs信号传递新进展及TLRs在中枢神经系统疾病中的研究现状进行综述。Toll-like receptors（TLRs）are pattern recognition receptors（PRRs）and attracted attention in the field of drug research broadly. TLRs can specific to identify the pathogen associated molecular patterns（PAMPs）and play an important role in the process of activation of innate immune and regulating acquired immune. In recent years,studies on TLRs signal transduction associated with the central nervous system diseases progress quickly. The research status about new progresses of TLRs signaling and their roles in the central nervous system diseases were reviewed.

关 键 词：TOLL样受体 信号转导 中枢神经系统疾病 

分 类 号：R965[医药卫生—药理学]