气味的刺激大脑嗅觉功能磁共振成像研究  

The functional magnetic resonance imaging study of the olfactory cortex activation by smell of odors

作　　者：颜志平[1] 陈志伟[2] 卢建华[2] 罗万能[1] 饶志远[1] 苏素联[1] 王健[1] 

机构地区：[1]解放军第一七四医院医学影像科,厦门361003 [2]厦门大学磁共振与医学成像研究中心

出　　处：《功能与分子医学影像学（电子版）》2012年第4期26-29,共4页Functional and Molecular Medical Imaging(Electronic Edition)

基　　金：南京军区医学科技创新重点课题(09Z019)

摘　　要：目的采用血氧水平依赖功能磁共振成像技术(BOLD-fMRI)研究香臭气味刺激对不同健康志愿者嗅觉功能激活区的分布特点。方法对22名无嗅觉障碍的健康志愿者,利用愉快的香草醛和非愉快的硫化氢两种气体分别以组块设计进行刺激实验,采用单次激发梯度回波EPI序列扫描,使用MRIcro软件及SPM2软件数据后处理。结果愉快气体激活右侧大脑的体素明显比左侧多,主要激活额叶上、中和下回等;非愉快气体激活左侧大脑的体素明显比右侧多,主要刺激边缘叶、海马旁回、豆状核及丘脑背内侧核等。结论 BOLD-fMRI是研究人类嗅觉功能的有效方法,并且大脑嗅觉具有偏侧性,愉快气体激活以右侧大脑前区为主,非愉快气体激活以左侧大脑后区明显。愉快与非愉快气味对大脑左右脑区的激活在性别上没有显著性差异,同一种气味,左右利手也无显著性差异。Objective To identify regional activation of the human cerebral cortex in response to pleasant and unpleasant odors with functional MRI （fMRI） and to localize the olfactory centers and pathways. Method Twenty-two healthy volunteers were recruited in the study. Two kinds of odors were given to them through the personally developed instrument. One was vanillin, which was regarded as pleasant odor, and the unpleasant one was hydrogen sulfide. Block design was adopted in this experiment, and SE-EPI was performed on 1.5T MRI, the raw fMRI data were processed with MRIcro and SPM2 software. Results The pleasant odor activated the voxels in right hemisphere more than in left hemisphere, and the activation areas were present in gyrus frontalis superior, gyrus frontalis middle, gyrus frontalis inferior. Unpleasant odor activated the voxels in the left hemisphere more than in right hemisphere, and the activation areas were present in limbic lobe, parahippocampal gyrus, lenticular nucleus, tonsil of cerebellum and dorsomedial nucleus of thalamus. Conclusion BOLD-fMRI is a useful method for studying of human olfactory system.

关 键 词：功能磁共振成像 嗅觉 半球优势 

分 类 号：R445.2[医药卫生—影像医学与核医学] R338.3[医药卫生—诊断学]