1H-MRS与DTI在MHE星形细胞代谢评估中的价值  

Application of 1H-MRS and DTI in the evaluation of Metabolism of MHE Astrocytes

作　　者：袁文昭[1] 邓德茂[1] 段高雄[1] 武莹莹[1] 蒙建兴[1] 李敏[1] 

机构地区：[1]广西中医药大学第一附属医院放射科,南宁530023

出　　处：《功能与分子医学影像学（电子版）》2013年第4期19-22,共4页Functional and Molecular Medical Imaging(Electronic Edition)

基　　金：国家自然科学基金项目(81160439);广西自然科学基金重项目(2010GXNSFD013049)

摘　　要：目的探讨轻微型肝性脑病星形细胞代谢物含量与细胞水肿的关系。方法对12例年龄相近临床诊断为轻微型肝性脑病的患者行1H-MRS及DTI扫描,采用单体激励回波采集序列(STEAM)行右侧基底节区1H-MRS扫描,分别计算N-乙酰天门冬氨酸(NAA)、肌酸(Cr)、胆碱(Cho)、肌醇(mIns)及谷氨酰胺复合物(Glx)峰下面积,并计算与Cr的比值:NAA/Cr、(Cho+mIns)/Cr及Glx/Cr值。弥散张量成像(DTI)扫描技术采用单次激发平面回波成像(SS-EPI),其感兴趣区与1H-MRS一致,测量参数为平均扩散率(MD),将MD值与1H-MRS所测NAA/Cr、(Cho+mIns)/Cr及Glx/Cr值进行相关性分析。结果NAA/Cr、(Cho+mIns)/Cr及Glx/Cr与MD值均呈低度相关,r值分别为0.144、-0.286、0.108(P均>0.05)。结论 MHE患者的星形细胞代谢物的变化不能直接反应细胞水肿的程度,代谢物的含量不能直接完全反映病理生理变化。Objective To investigate the relationship between the brain astrocytic metabolites content and cell edema in minimal hepatic encephalopathy （MHE）. Methods Twelve patients of similar age underwent 1H - MRS and DTI scan with MHE. 1H-MRS of right basal ganglia were acquired using STEAM sequences.Peak area of each metabolite,including NAA, Cr, Cho, mlns and Glx and their ratios to Cr were measured, respectively. DTI were acquired using SS-EPI sequences as the same region of interest （ROI）. The mean diffusivity （MD） were measured. The MD value were analyzed respectively with NAA/Cr, （Cho ＋ mIns）/Cr and Glx/Cr value. Results The value ofr between NAA/Cr, （Cho ＋ mIns）/Cr, Glx/Cr and MD were 0.144,- 0.286 and 0.108, respectively （P 〉 0.05）. There were no correlation between MD values and NAA/Cr, （Cho ＋ mlns）/Cr, Glx/ Cr. Conclusion The change of astrocytes metabolites of MHE does not directly replect the degree of astrocytic swelling. The contents of metabolites can not fully reflect the pathological changes.

关 键 词：轻微型肝性脑病 磁共振成像 磁共振波谱 弥散张量成像 

分 类 号：R445.2[医药卫生—影像医学与核医学]