呋塞米在输尿管镜钬激光碎石术中的应用  

APPLICATION OF FUROSEMIDE IN URETEROSCOPY WITH HOLMIUM LASER LITHOTRIPSY FOR URETERAL STONES

作　　者：纪建磊 钟修龙[1] 宋英英[1] 毛昕[1] 宋树欣[1] 刘勇[1] 

机构地区：[1]青岛大学附属医院泌尿外科,山东青岛266003

出　　处：《齐鲁医学杂志》2014年第3期241-243,共3页Medical Journal of Qilu

摘　　要：目的探讨呋塞米在输尿管镜钬激光碎石术中应用预防术后感染的效果。方法 2011年1月—2013年6月,选取适合行输尿管镜钬激光碎石术的病人172例,随机分为利尿剂组88例和对照组84例。两组均给予同级别抗生素预防感染,钬激光光纤将结石击碎并通畅引流后,利尿剂组与对照组分别给予呋塞米20mg和等体积生理盐水静脉推注,术后均置双J管,并留置导尿管充分引流。比较两组术后全身炎症反应综合征(SIRS)发生率。结果利尿剂组与对照组术后SIRS发生率分别为6.8%(6/88)、17.9%(15/84),差异有显著性(χ2=4.89,P<0.05)。结论应用呋塞米能够减少炎症物质反流,同时抑制细菌及毒素的吸收,从而降低输尿管镜钬激光碎石术后感染发生率。Objective To assess the efficacy of furosemide in prevention of postoperative infection in patients undergoing ureteroseopy with holmium laser （HLL） lithotripsy. Methods From January 2011 to June 2013, 172 patients suited for uret- eroscopy with HLL were enrolled and randomized to two groups as diuretic group （n = 88） and control group （n = 84）. Same grade antibiotics were given to patients in both groups for infection prevention. When the stones were smashed and drained smoothly, in- travenous furosemide （20 rag） was given to patient in the diuretic group, and same volume of normal saline to those in the control. A D-J stent and catheter were placed after operation. The incidence of systemic inflammatory response syndrome （SIRS） was com- pare between the two groups. Results The incidence of SIRS in diuretic group and control group was 6.8% （6/88） versus 17.9% （15/84）, the difference was significant （x2 =4.89,P〈0.05）. Conclusion Furosemide can reduce the reflow of inflam- matory substance, and, at the same time, inhibit the absorption of bacteria and toxin, thus decrease postoperative infection after endoscopic holmium laser lithotripsy for ureteral stones.

关 键 词：输尿管结石 碎石术 激光 呋塞米 感染 

分 类 号：R693.4[医药卫生—泌尿科学]