剑麻皂素对急性血瘀大鼠血液流变性的影响研究  

Study the Effect of Tigogenine on Hemorheological Abnormality in Rats with Acute Blood Stasis

作　　者：袁志林[1,2] 李燕婧[1,2] 钟正贤[1,2] 陈学芬[1,2] 

机构地区：[1]广西中医药研究院,广西南宁530022 [2]广西中药质量标准研究重点实验室,广西南宁530022

出　　处：《广西科学》2014年第3期279-282,共4页Guangxi Sciences

基　　金：广西自然科学基金项目(2010GXNSFBOI3086)资助

摘　　要：【目的】研究剑麻皂素对急性血瘀大鼠血液流变性的影响。【方法】采用皮下注射大剂量肾上腺素加寒冷刺激的方法制备大鼠急性血瘀模型,给予不同剂量的剑麻皂素,观察用药后大鼠的血液流变学指标。【结果】与正常对照组比较,急性血瘀模型大鼠的全血黏度(BV)、血浆黏度(PV)均明显升高(P<0.01);剑麻皂素可以明显降低急性血瘀大鼠的全血黏度、血浆黏度、红细胞聚集指数(EAI)、红细胞压积(HCT)、红细胞变形指数(DI)、红细胞电泳时间、血沉(ESR)等指数,同时能降低血浆纤维蛋白原(Fib)含量,延长凝血酶原时间(PT)、凝血酶时间(TT)和活化部分凝血活酶时间(APTT)(P<0.01)。【结论】剑麻皂素能够明显改善急性血瘀大鼠血液流变性。[Objective]The effect of tigogenine on hemorheological abnormality was evaluated in the rats with acute blood stasis.[Methods]The model of acute blood stasis in rats was made by subcutaneously inj ecting amount of epinephrine and ice water simulation,in whic the changes of hemorheologic indexes were observed after giving different doses of tigogenine.[Results]The viscosity of whole blood （BV）and plasma （PV）in the rats of acute blood stasis model were significantly higher than those in the normal group（P〈0.01）.The tigogenine reduced the vis-cosity of whole blood and plasm,erythrocyte aggregation（EAI）,the hematocrit（HCT）,de-formed index（DI）,electrophoresis time（ET）,erythrocyte sedimentation rate （ESR）and so on. Also,the content of fibrinogen（Fib）was increased while prothrombin time（PT）,activated par-tiac thrombin time（APTT）and thrombin time（TT）were shortened.[Conclusion]Tigogenine can improve the hemorheological abnormality in rats with acute blood stasis.

关 键 词：剑麻皂素 急性血瘀模型 血液流变学 大鼠 

分 类 号：R285.5[医药卫生—中药学]