西酞普兰对急性心肌梗死PCI术后伴发抑郁预后的影响  

The clinical effect of Citalopram in patients with depression after undergoing the emergency PCI

作　　者：李锦爽[1] 王万虹[1] 程勇[1] 

机构地区：[1]南京鼓楼医院集团宿迁市人民医院心血管内科,江苏省宿迁市223800

出　　处：《中国心血管病研究》2014年第7期653-655,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的 探讨西酞普兰干预对急性心肌梗死PCI术后伴发抑郁患者预后的影响.方法 将56例急性心肌梗死PCI术后伴发抑郁的患者随机分为西酞普兰治疗组27例和对照组29例.治疗组在PCI术后常规心脏药物治疗基础之上加用西酞普兰20mg口服,1次/d,治疗12周;对照组PCI术后只给以常规心脏药物治疗.结果 12周后治疗组患者心电图ST段压低次数、压低持续总时间、缺血总负荷、6 min步行距离及心脏收缩功能较对照组均有所改善.结论 西酞普兰在一定程度上可以改善急性心肌梗死PCI术后伴发抑郁患者近期预后.Objective To observe the clinical effect of Citalopram in treating the depression after the emergency PCI.Methods Fifty six patients with depressive disorder after PCI were randomed into the therapy group and control group.Patients in the therapy group were treated with 20 mg of Citalopram one day on the basis of regular cardiac medicine therapy for 12 weeks.Patients in the control group were only treated with regular cardiac medicine therapy.Results After treating for 12 weeks,the symptom of angina,6 minute walk test,systolic heart function were better than that of the control group.Conclusion Antidepressant treatment of Citalopram can relieve the symptom of angina pectoris and depression,improve exercise tolerance and heart funtion in patients with depression after PCI.

关 键 词：急性心肌梗死 经皮冠状动脉介入治疗 抑郁 西酞普兰 

分 类 号：R542.22[医药卫生—心血管疾病]