多种生化指标在不同性别早发冠心病患者中的特征分析  

Analysis of the Characteristics of Many Biochemical Criterions in Patients with Premature Coronary Heart Disease of Different Genders

作　　者：姜昆[1] 赵景波[1] 王宁宁[1] 杨晓珊[1] 崔荣[2] 

机构地区：[1]哈尔滨医科大学公共卫生学院,黑龙江哈尔滨150081 [2]哈尔滨市南岗区大成社区卫生服务中心,黑龙江哈尔滨150001

出　　处：《黑龙江医学》2014年第7期771-773,共3页Heilongjiang Medical Journal

基　　金：黑龙江省自然科学基金项目(D201235)

摘　　要：目的探讨多种生化指标在不同性别早发冠心病患者中的流行特征和规律。方法选取早发冠心病患者332例,按性别分为两组进行比较,其中男性147例,女性185例。收集研究对象的临床资料及采集患者入院24 h内空腹12 h肘静脉血,记录血糖(GLU)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL)、载脂蛋白A(apoA)、载脂蛋白B(apoB)、LP(a)(脂蛋白a)、纤维蛋白原定量(FG)、D-二聚体定量(DD)、总胆红素(TBIL)、尿酸(UA)的数值。结果男性组的文化程度、月均收入、高血压病史、超重(BMI≥24)、吸烟饮酒史比例高于女性组(P均<0.05)。女性组TC、HDL-C、LDC、apoA、FG、DD水平高于男性组,而TG、TBIL、UA水平则显著低于男性组,差异有统计学意义(P均<0.05)。两组GLU、apoB、LP(a)水平差异无统计学意义(P均>0.05)。结论大部分心血管病危险因素在早发冠心病患者中存在着性别差异,因此有必要在中青年人群中进行整体心血管风险的评估,并采取综合性个体化干预措施,以降低未来心血管不良事件的风险。Objective To investigate the epidemiological characteristics and patterns of risk factors in patients of different genders with premature coronary heart disease.Methods A total of 332 patients with premature coronary heart disease were divided into female group （n=147） and male group （n=185）.Collecting their clinical data and venous blood without food in admission within 24h.Writing down the values of blood glucose records （ GLU） ,total cholesterol （ TC） ,triglyceride （ TG） ,high density lipoprotein （ HDL-C） ,low-den-sity lipoprotein protein （LDC）,apolipoprotein A （APOA）,apolipoprotein B （APOB）,lipoprotein a （LP （a））,fibrinogen （FG）,D-Di-mer （DD）,the total bilirubin （TBIL） and uric acid （UA）.Results The cultural level,the average monthly income,the history of hyper-tension,the CHD family history,overweight （BMI＆gt;=24） and the history of smoking and drinking in male group were higher than those in female group （ P〈0.05 ）.The levels of total cholesterol ,high density lipoprotein ,low density lipoprotein ,apolipoprotein A ,fibrinogen and D-Dimer in female group were higher than those in male group , but the triglycerides level , total bilirubin level and uric acid level were significantly lower than theirs （ P ＆lt;0.05 ）.The levels of blood glucose , apolipoprotein B , lipoprotein （ a ） in two groups showed no significant difference in statistics （ P〉0.05 ）.Conclusion Most of cardiovascular risk factors in patients with premature coronary heart disease are different in different genders.It is necessary to assess the overall cardiovascular risk in middle -aged crowd,and take a compre-hensive individualized interventions to reduce future cardiovascular the risk of adverse events .

关 键 词：血糖 血脂 纤维蛋白原定量 D-二聚体定量 总胆红素 尿酸 早发冠心病 

分 类 号：R541.1[医药卫生—心血管疾病]