主动免疫联合中药治疗封闭抗体不足性反复自然流产的临床观察  

Clinical observation on active immunity combined with traditional Chinese medicine in treatment of recurrent spontaneous abortion with lack of blocking antibodies

作　　者：赖有行[1] 李正梅[1] 詹新林[1] 周才[1] 周晓莹[1] 叶青[1] 

机构地区：[1]广东省妇幼保健院检验科,广东广州510010

出　　处：《中国妇幼保健》2014年第21期3486-3488,共3页Maternal and Child Health Care of China

基　　金：广东省卫生厅中医药科研基金资助(20122175)

摘　　要：目的:探讨反复自然流产(RSA)接受中药和主动免疫治疗相结合的临床疗效。方法:对87例原因不明反复自然流产封闭抗体阴性的患者,随机分成免疫治疗组(主动免疫治疗)41例和联合治疗组(主动免疫治疗+服用中药)46例。免疫治疗组只进行淋巴细胞主动免疫治疗,联合治疗组在淋巴细胞主动免疫治疗基础上,辅以中药联合治疗,免疫治疗每月1次,3次为1个疗程,并观察其妊娠结局。结果:87例均完成了治疗,第1疗程后,联合治疗组的封闭抗体(BA)转阳率为60.9%,免疫治疗组为41.5%,2组间比较差异有统计学意义(P<0.05)。第2疗程后,联合治疗组BA总转阳率为89.1%,免疫治疗组为78.1%,在总转阳率上高于免疫治疗组,但差异无统计学意义(P>0.05);联合治疗组妊娠成功率为89.2%,高于免疫治疗组的70.7%,差异有统计学意义(P<0.05)。结论:主动免疫联合中药治疗封闭抗体不足性反复自然流产疗效肯定,有利于提高反复流产患者的保胎成功率。Objective： To explore the clinical efficacy of active immunity combined with traditional Chinese medicine in treatment of recurrent spontaneous abortion （RSA） . Methods： Eighty- seven RSA patients with lack of blocking antibodies were randomly divided into immunotherapy group （41 patients） and combination therapy group （46 patients） . The patients in immunotherapy group were treated with active immunotherapy; tbe patients in combination therapy group were treated with active immunotherapy combined with traditional Chi- nese medicine ; immunotherapy was performed once a month, one course of treatment included three times of immunotherapy ; the pregnancy outcomes in the two groups were observed. Results： Eighty - seven cases had finished the treatment. After the first course of treatment, the positive conversion rates of blocking antibodies in combination therapy group and immunotherapy group were 60. 9% and 41.5% , respective- ly, there was statistically significant difference between the two groups （P 〈 0. 05） . After the second course of treatment, the positive con- version rates of blocking antibodies in combination therapy group and immunotherapy group were 89. 1% and 78.1%, respectively, the positire conversion rate of blocking antibodies in combination therapy group was higher than that in immunotherapy group, but there was no statistically significant difference （P 〉 0. 05） ; the successful rate of pregnancy in combination therapy group was 89.2%, which was statisti- cally significantly higher than that in immunotherapy group （70.7%） （P 〈 0. 05） . Conclusion： The curative effect of active immunity combined with traditional Chinese medicine in treatment of RSA with lack of blocking antibodies is good, and the method is helpful to im- prove the successful rate of abortion prevention in RSA patients.

关 键 词：反复自然流产 封闭抗体 免疫治疗 

分 类 号：R714.21[医药卫生—妇产科学]