宁夏回、汉民族血清热应激蛋白70水平与2型糖尿病的相关性研究  

The relationship between the expression level of serum HSP70 and type 2 diabetes in Moslem and Han people of Ningxia

作　　者：陈丽军[1] 田如龙 宋辉[3] 赵川[3] 刘贺荣[3] 王勇[3] 

机构地区：[1]宁夏医科大学总医院内分泌科,银川750004 [2]宁夏吴忠市人民医院 [3]宁夏医科大学公共卫生学院

出　　处：《中国糖尿病杂志》2014年第7期625-629,共5页Chinese Journal of Diabetes

基　　金：银川市科技发展项目(201134)

摘　　要：目的探讨宁夏回、汉民族血清热应激蛋白70(HSP70)表达水平与T2DM发病的关系。方法应用病例对照研究法收集T2DM患者(T2DM组)201例,另选健康体检者(NC组)201名,采用ELISA检测两组血清HSP70的表达水平。结果 T2DM组血清HSP70蛋白表达水平明显高于NC组[(0.147±0.126)vs(0.110±0.113)ng/ml](t=3.066,P=0.002)。血清HSP70高表达者患T2DM风险是低表达者的2.307倍。回族人群血清HSP70表达水平高于汉族人群[(0.145±0.130)vs(0.114±0.111)ng/ml](t=2.591,P=0.010);回族人群HSP70高表达风险是汉族人群的1.760倍。腹型肥胖、非腹型肥胖T2DM组与NC组血清HSP70表达水平[(0.152±0.128)vs(0.128±0.119)vs(0.111±0.121)ng/ml]差异有统计学意义(F=5.335,P=0.005)。结论 T2DM患者中血清HSP70表达水平明显高于健康人群,高表达者患T2DM的风险高于低表达者。回族人群血清HSP70表达水平高于汉族,HSP70高表达的风险亦高于汉族。腹型肥胖T2DM患者血清HSP70表达水平高于正常人群。血清HSP70水平可能是影响T2DM患病的重要因素之一。Objective To investigate the relationship between serum heat shock protein 70 （HSP70） and type 2 diabetes mellitus in Moslem versus Han people in Ningxia. Methods According to casecontrol study,201 patients with type 2 diabetes （T2DM group） and 201 healthy examinees （NC group） tested in Wuzhong People＇ s Hospital and Second Affiliated Hospital of Ningxia Medical University from February 2009 to December 2010 were enrolled in the study. The expression levels of serum HSPT0 were detected by ELISA. Results The expression of serum HSP70 was significantly higher in T2DM group than in control group [（0. 147±0. 126） vs （0. 110±0. 113） ng/ml,P=0. 0021. And the OR value was 2. 037 （95%CI 1. 538±3. 460, P〈0. 001） in T2DM patients with high expression of HSPT0 versus low expression of serum HSPT0 . The expression level of HSPT0 was significantly higher in Moslem people than in Han people [（ 0. 147 ± 0. 130） vs （0. 114 ±_0. 111 ） ng/ml] （ t = 2. 591, P = 0. 010）, with corresponding OR value of 1. 760 （P = 0. 005） in Moslem people versus Han people. There was statistically significant difference in the expression levels of HSP70 among abdominally obese, non-abdominally obese T2DM group and control group[（0. 152 ± 0. 128） vs （0. 128 ± 0. 119） vs （0. 111 ± 0. 121）ng/ml]（F=5. 335,P=0. 005）. Conclusion The expression level of serum HSP70 is obviously higher in T2DM group than in healthy people, and significantly higher in Moslem people than in Han people, and significantly higher in abdominally obese people than in normal people. Therefore, HSP70 may be one of the important factors influencing the onset of T2DM.

关 键 词：热应激蛋白70 糖尿病 2型 回族 汉族 患病风险 

分 类 号：R587.1[医药卫生—内分泌]