基于对小鼠利尿与泻下作用探讨京大戟与甘草配伍禁忌的理论依据  

Theoretical basis of imcompatibility of Euphorbiae Pekinensis Radix and Glycyrrhizae Radix et Rhizoma based on diuretic and purgative effects on mice

作　　者：许瑞[1] 陶伟伟[2] 段金廒[2] 何苗[3] 王梦[1] 徐立[1] 

机构地区：[1]南京中医药大学药物安全性评价中心,江苏南京210046 [2]南京中医药大学江苏省方剂高技术研究重点实验室,江苏南京210046 [3]南京中医药大学药学院,江苏南京210046

出　　处：《中草药》2014年第14期2056-2059,共4页Chinese Traditional and Herbal Drugs

基　　金：国家重点基础研究发展计划("973"计划)资助项目(2011CB505300;2011CB505303)

摘　　要：目的探讨京大戟与甘草配伍禁忌的理论依据。方法比较京大戟与甘草合用前后对正常小鼠的利尿及泻下作用,采用称质量法测定正常小鼠排尿量;采用炭末法测定正常小鼠的排便情况。结果在《中国药典》2010年版等效剂量范围内,京大戟粉末的利尿作用强于其水提液;甘草水提液未表现出促进或抑制利尿的作用;京大戟粉末与甘草水提液合用,给药后1 h内尿量明显减少;京大戟与甘草合煎液给药未引起尿量明显变化。京大戟粉末和甘草水提液混合液给药与等剂量的京大戟比较泻下作用无明显差异。结论在药典用量范围内,甘草水煎液可明显抑制京大戟的利尿作用。基于药性分析其机制表明,甘草的甘缓之性减缓了京大戟的泻水逐饮之药势,可能是京大戟与甘草配伍禁忌的机制之一。Objective To investigate the theoretical basis of incompatibility of Euphorbiaepekinensis Radix （EPR） and Glycyrrhizae Radix et Rhizoma （GtLR）. Methods In order to compare the effects of EPR used alone and combined with GRR, the diuretic effect was studied by weighing method to observe the urine output of normal mice, while the purgation effect was studied by observing the defecation time, feces pellets, and feces shape after drug administration. Results In the equivalent dose range of China Pharmacopoeia 2010, the diuretic effect of EPR powder is stronger than its aqueous extract; GRR aqueous extract did not show any promoting or suppressing effect on the diuresis; Within 1 h after coadministration of EPR powder and GRR aqueous extract, urine output was significantly reduced, suggesting that GRR might inhibit the diuretic effect of EPR; The co-detection of EPR and GRR did not cause the obvious changes of urine output. There was no significant purgative effect of EPR powder alone and coadministered with GRR aqueous extract at the same dose level. Conclusion The diuretic effect of EPR can be suppressed by GRR in the equivalent dose range of China Pharmacopoeia 2010, suggesting that the sweet and mitigation property of GRR relieving the effect of removing water retention by purgation is one of the incompatibility theoretical basis between EPR and GRR.

关 键 词：京大戟 甘草 泻水逐饮 配伍禁忌 药性机制 

分 类 号：R285.5[医药卫生—中药学]