杭州市健康人群血清中36项理化指标的参考区间调查  

Research for the Reference Ranges of 36 Physicochemical Indexes in the Serum of Healthy Individuals in Hangzhou

作　　者：程玥[1,2] 徐思琪[1,2] 刘春华[1,2] 廖昭平 陶志华[1,2] 

机构地区：[1]温州医科大学检验医学院生命科学学院,温州325035 [2]浙江大学附属第二医院,杭州310009

出　　处：《科技通报》2014年第7期32-36,119,共6页Bulletin of Science and Technology

摘　　要：目的：通过测定浙江省杭州市健康成年人群的ALB等36项理化指标,建立该36项指标的生物参考区间。方法：以杭州市8区5县（市）的健康人群为调查对象，征集5组年龄段（19～29岁、30～39岁、40～49岁、50～64岁和大于65岁）的男女志愿者523例（男257例、女266例），对其血清中的ALB等36项理化指标进行了检测分析。结果：杭州市健康体检人群中的ALB、ALT、AST、CK、CL、GGT、HDL、LDL、LIP、NA、TG、UREA、FOL在男女组间和不同年龄组间的差异均有统计意义（P＞0.05），ALP、CR、TBIL、TP、TRF、UA、Fe、AFP、FER、CEA、CA125、PSA只在男女组间的差异有统计意义，ALP、CR、TBIL、UA、Fe、AFP、PSA男性水平高于女性，TP、TRF、CA125女性水平高于男性。Ca、GLU、LDH、Mg、P、TC、PTH在不同年龄组间有统计意义，GLU、LDH、Mg、TC、PTH随着年龄的增加而增加，Ca和P随着年龄的增加而减少。AMY、K、VB12、INS在男女组间和不同年龄组间的差异均不具有统计学意义。结论：杭州市及周边地区的健康人群血清中的Fe、TG、HDL、LDL、CR、UA、UREA、AFP、CEA、CA125、PSA、FER水平在男女分组有显著性差异，建议在临床诊断的健康评估时，应根据性别设立不同的参考区间。UA、UREA、TC、TG、LDL、GGT、ALB水平与相关报道差异较大，因此杭州地区有必要建立自己的正常值参考范围。Objective：The research project was in the interest of establishing the reference intervals of 36 physicochemical indexes for healthy adults in the location of Hangzhou, Zhejiang province. Methods：The respondents of the study were healthy residents in Hangzhou （including its 8 districts and 5 countries）, the number of which was 523 （including 257 male and 266 female samples）. All the samples were divided into five different age groups （19-29, 30-39, 40-49, 50-64 and 65 or more） to analyze 36 physicochemical indexes in serum. Result：Statistical significance （P＆gt;0.05） was obtained among various age groups and genders in ALB, ALT, AST, CK, CL, GGT, HDL,LDL,LIP,NA,TG,UREA,FOL. Only gender-related difference in reference intervals were observed in ALP,CR,TBIL,TP,TRF,UA,Fe,AFP,FER,CEA,CA125,PSA. The levels of ALP, CR, TBIL, UA, Fe, AFP, PSA were higher in male samples than female ones. The levels of TP, TRF, CA125 were higher in female samples. Age-related difference of reference intervals was observed in Ca, GLU, LDH, Mg, P, TC, PTH. GLU, LDH, Mg, TC, PTH have positive correlation with age, while Ca and P have negative correlation. There is no statistical significance in AMY, K, VB12, INS among various age groups or genders. Conclusion：There is significant difference in Fe, TG, HDL, LDL, CR, UA, UREA, AFP, CEA, CA125, PSA, FER between genders, considering healthy residents in Hangzhou. Distinguishing reference interval of those indexes in the classification of sexes is recommended in clinical diagnosis. Levels of UA, UREA, TC, TG, LDL, GGT, ALB of healthy adults in Hangzhou show gaps with related studies in other locations. As a result, it’s necessary to modify native reference intervals in consideration of those indexes.

关 键 词：健康人群 血清 参考区间 

分 类 号：R446.11[医药卫生—诊断学]