基于多重氢键的寡聚芳酰胺自组装囊泡  

Self-Assembly of Vesicles from Oligoaramide Based on Multiple Hydrogen Bonds

作　　者：贺有周[1] 刘云[1] 刘鹏[1] 冯文[1] 袁立华[1] 

机构地区：[1]1~lJiI大学化学学院,原子核科学技术研究所,辐射物理及技术教育部重点实验室,成都610064

出　　处：《物理化学学报》2014年第8期1501-1508,共8页Acta Physico-Chimica Sinica

基　　金：国家自然科学基金(21172158);国家自然科学基金国家基础科学人才培养基金(J1210004,J1103315)资助项目~~

摘　　要：六重氢键的异互补寡聚芳酰胺双股分子链在自组装过程中表现出极高的顺序专一性.本文借助扫描电镜(SEM)、透射电镜(TEM)和动态光散射(DLS)等实验手段,研究了氢键编码顺序为DADDAD-DADDAD的寡聚芳酰胺分子1及异互补分子2(ADAADA-ADAADA)存在下的自组装行为.实验结果表明,分子1在四氢呋喃/甲醇(体积比为85/15)和单一溶剂丙酮中都能组装成大小均匀的囊泡结构,并且囊泡的尺寸随着溶液浓度的增加而增大;当加入异互补分子2后,囊泡则转变成实心球.利用荧光显微镜,发现该囊泡能很好地包裹荧光分子(罗丹明B),通过进一步分子结构修饰有可能实现药物包埋和缓释方面的应用.Six-hydrogen-bonded oligoaramide heteroduplexes demonstrate extremely high sequencespecificity and tunable stability during their selfassembly. The selfassembly behavior of molecular oligoaramide 1 arrayed in a DADDAD-DADDAD sequence and that in the presence of oligoaramide 2 with an ADAADA- ADAADA sequence were examined using multiple techniques, including scanning electron microscopy （SEM）, transmission electron microscopy （TEM）, and dynamic light scattering （DLS）. Results from these experiments indicate that I can selfassemble to vesicles with uniform shapes in both tetrahydrofuran/methanol （V/V, 85/15） and acetone, the size of which increased with an increase in solution concentration. Upon addition of the corresponding complementary 2, the vesicles turned into solid balls. Fluorescence microscopy experiments revealed that the vesicles were able to encapsulate the fluorescence molecules （Rhodamine B）. With further modification of molecular structures, these vesicles may hold potential for applications as drug carrier as well as in controlledrelease technology.

关 键 词：自组装 囊泡 寡聚芳酰胺 氢键 双股分子链 

分 类 号：O641.3[理学—物理化学]