促进眼用制剂角膜渗透性的研究进展  

Research progress on improving the corneal permeability of ophthalmic preparations

作　　者：陈菊明[1,2] 王文月[1,2] 庄珊珊[1,2] 宋洪涛[1] 

机构地区：[1]南京军区福州总医院药学科,福建福州350025 [2]福建医科大学药学院,福建福州350108

出　　处：《中国医院药学杂志》2014年第14期1227-1231,共5页Chinese Journal of Hospital Pharmacy

基　　金：福建省科技计划重点项目(编号:2008Y0058)

摘　　要：为促进眼用制剂的角膜渗透性提供方案参考。通过检索国内外的相关文献,对促进眼用制剂角膜透过性的各类方法展开综述。药物的角膜渗透性是决定眼用制剂生物利用度的主要因素。目前,较为行之有效的改善眼用制剂角膜渗透性的方法就是添加角膜渗透促进剂和应用新技术来制备各类眼用制剂。To provide referenced plans for improving the corneal permeability of ophthalmic preparations. To summarize the methods of improving the corneal permeability of ophthalmic preparations by retrieving domestic and abroad literature. Its bioavailability depends on the corneal permeability of drugs. At present, adding corneal penetrating promoter and applying the new technologies to prepare various kinds of ophthalmic preparations are the effective means to improve the corneal permeability of ophthalmic preparations.

关 键 词：眼用制剂 生物利用度 角膜渗透促进剂 制剂新技术 

分 类 号：R94[医药卫生—药剂学]