血浆N-端脑利钠肽前体在心力衰竭中的应用价值  

The value of plasma N- terminal pro brain natriuretic peptide in congestive heart failure

作　　者：黄清容[1] 何茂婷 

机构地区：[1]广东省英德市人民医院检验科,广东英德513000

出　　处：《中国医学工程》2014年第6期17-18,共2页China Medical Engineering

摘　　要：目的观察心力衰竭患者的血浆N-端脑利钠肽前体(NT-proBNP)浓度水平,并探讨其临床应用价值。方法选取来英德市人民医院诊治的心力衰竭患者295例,按NYHA心功能分级标准分为4组,选择健康体检者50例作为对照组,均采用电化学发光法检测其血浆NT-proBNP浓度,统计学采用方差分析。结果心力衰竭各级患者的血浆NT-proBNP水平明显高于对照组,且随心衰的程度加重而增加,各组差异具有统计学意义(P<0.01)。结论血浆NT-proBNP在心力衰竭的早期诊断、预后评估及危险分层中具有显著的临床价值。[ Objective ] To observe the plasma N- - terminal pro brain natriuretic peptide in patients with congestive heart failure （NT-proBNP） concentrations, and to explore its clinical application value. [ Methods ] 295 patients with heart failure in our hospital cases, according to the NYHA cardiac functional grading standards are divided into four groups, and 50 health subjects were selected as control group, both the levels of NT-proBNP were detected by electrochemical luminescence method, statistically by analysis of variance. [ Results ] The levels of plasma NT-proBNP levels in patients with heart failure was significantly higher than that in control group, and with the increase of the severity of heart failure, with statistically significant difference （P〈0.01）. [ Conclusion ] NT-proBNP has significant clinical value in early diagnosis, prognosis and risk stratification in heart failure.

关 键 词：心力衰竭 NT-PROBNP 

分 类 号：R541.61[医药卫生—心血管疾病]