幽门螺旋杆菌感染与维持性血液透析患者微炎症的关系  

Helicobacter pylori infection and microinflammatory in maintenance hemodialysis patients

作　　者：杨京新[1] 刘恩波[1] 王碧飞[1] 

机构地区：[1]深圳市罗湖区人民医院肾内科,广东深圳518000

出　　处：《中国医学工程》2014年第7期3-4,共2页China Medical Engineering

基　　金：深圳市罗湖区科技局(2011-7)

摘　　要：目的研究幽门螺旋杆菌(HP)感染与维持性血液透析患者微炎症之间的关系。方法选择深圳市罗湖区人民医院2011年3月-2012年3月间诊治的100例血液透析患者,对其存在HP感染率进行分析,比较有无感染HP患者的血清C反应蛋白(CRP)、血清前白蛋白(PA)、肿瘤坏死因子(TNF-α)以及血液血红蛋白(Hb)浓度的不同。结果 100例患者中,共有26例出现HP感染,血液透析人群与正常人群感染HP的概率未见明显差异,无统计学意义(P>0.05)。HP阳性的血液透析患者血清CRP明显高于HP阴性患者;HP阳性的血液透析患者Hb、血清PA水平明显低于HP阴性患者;HP阳性的患者经过抗HP治疗后,CRP水平明显下降,同时Hb、血清PA及TNF-α水平也程度不等的回升,但是Hb变化不明显。结论通过对这类患者的微炎症实施治疗,能够明显降低患者出现心脑血管疾病的相关性,提高患者的生存治疗,缓解医疗行业的负担,同时也降低患者的经济负担。【Objective】To study the relationship between Helicobacter pylori（HP） infection and inflammation in hem dialysis patients between micro. 【Methods】 A hospital in March 2011 to 100 hem dialysis patients between diagnosis and treatment in March 2012, its existence HP infection were analyzed, comparing the presence or absence of infection in patients with serum C HP-reactive protein（CRP）, serum former White protein（PA） level, the type of tumor necrosis factor（TNF-α）, and the hemoglobin concentration in blood. 【Results】 The study showed that 100 patients were chosen for this article, a total of 26 cases of HP infection, the probability of hem dialysis population infected with HP ＇s normal population no significant difference was not statistically significant（P〈0.05）. HP-positive serum CRP in hem dialysis patients was significantly higher than HP-negative patients; HP hem dialysis patients with positive Hb, serum levels were significantly lower than the HP PA-negative patients; HP positive patients after anti-HP therapy, CRP levels were significantly decreased, while Hb,PA, and TNF-α serum levels varying degrees of recovery, but Hb did not change significantly. 【Conclusion】These patients through the implementation of micro- inflammation treatment, patients can significantly reduce the correlation of cardiovascular and cerebrovascular diseases, improve the survival of patients treated, and ease the burden on the healthcare industry, while also reducing the financial burden on patients.

关 键 词：幽门螺杆菌 维持性血液透析 微炎症 临床分析 

分 类 号：R459.5[医药卫生—治疗学]