静脉胺碘酮和维拉帕米转复阵发性心房颤动疗效对比观察  

The comparative study of intravenous amiodarone and verapamil in treatment of paroxysmal atrial fibrillation

作　　者：蒙应东[1] 

机构地区：[1]广东省茂名市人民医院,广东茂名525000

出　　处：《中国医学工程》2014年第7期14-15,共2页China Medical Engineering

摘　　要：目的观察胺碘酮与维拉帕米治疗阵发性心房颤动的疗效。方法将80例心房颤动患者随机均分为两组,胺碘酮组40例,男21例,女19例,给予静脉胺碘酮治疗;维拉帕米组40例,男18例,女22例,给予静脉维拉帕米治疗。对比两组转复率、平均起效时间和不良反应发生率。结果胺碘酮组与维拉帕米组转复率分别为83.78%与82.31%,差异无统计学意义(P>0.05);两组平均起效时间分别为25.68 min和15.48 min,差异有统计学意义(P<0.05);两组不良反应事件发生率分别为2.50%和12.50%,两组差异有统计学意义(P<0.05)。结论胺碘酮与维拉帕米的治疗转复率无统计学差异,表明两组治疗效果相当;维拉帕米组的平均起效时间明显快于胺碘酮组;胺碘酮组的不良事件发生率明显低于维拉帕米组。【Objective】To observe the efficacy of intravenous amiodarone and verapamil cardioversion in the treatment of paroxysmal atrial fibrillation. 【Methods】80 patients with atrial fibrillation were randomly divided into two groups： the amiodarone group was with 40 patients： 21 males and 19 females, and they were taken with intravenous amiodarone. The verapamil group was with 40 cases, 18 males and females 22 cases, was given with intravenous verapamil therapy. The cardioversion rate, average onset time and adverse reaction rates of the two groups were compared. 【Results】The cardioversion rates of the amiodarone group and the verapamil group were 83.78% and 82.31%, and the difference was not statistically significant（P〉0.05）. The mean onset time for the two groups was 25.68 min and 15.48 min, and the differences was with statistical significance（P〈0.05）. The adverse event rates for the two groups were 2.5% and 12.50%, the difference was statistically significant（P〈0.05）. 【Conclusions】The cardioversion therapy rate of amiodarone and verapamil was without significant difference, indicating the effect of the two groups was quite equal. The average onset time of the verapamil cardioversion group is significantly faster than the amiodarone group. The incidence of adverse events of amiodarone group is significantly lower than verapamil cardioversion group.

关 键 词：胺碘酮 维拉帕米 阵发性心房颤动 转复率 

分 类 号：R541.75[医药卫生—心血管疾病]