人参多糖注射液对环磷酰胺增效减毒作用实验研究  

Experimental Study on Synergistic and Attenuated Effect of Ginseng Polysaccharide Injection among Animals Treated with Cytoxan

作　　者：吕新勇[1] 周军[1] 孙晓萍[1] 刘莉娜[1] 王振中[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司/中药制药过程新技术国家重点实验室,连云港222002

出　　处：《世界科学技术-中医药现代化》2014年第6期1372-1376,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：科学技术部国家基础发展计划"973计划"项目(2010CB735604):新药研制过程化学机理-中药制药过程控制技术模式和方式研究;负责人:萧伟

摘　　要：目的:研究人参多糖注射液对肿瘤的抑制作用及其对免疫功能的影响,并探讨其对环磷酰胺(CTX)化疗的增效减毒作用。方法:以S180瘤株ICR小鼠作为病理模型,随机分为模型组、未造模组、CTX组、联合用药组。连续给药10天后,测定其抑瘤率、白细胞数、胸腺指数和脾指数。同时复制CTX致免疫低下小鼠模型,考察人参多糖注射液对血清溶血素和单核细胞吞噬功能的影响。结果:人参多糖注射液和CTX合用时,能显著提高抑瘤率;同时减轻CTX的毒副作用;对CTX致免疫低下功能有一定的改善功能。结论:人参多糖注射液对CTX具有明显的增效减毒作用。This article was aimed to study the inhibitory effect of ginseng polysaccharide injection on tumor growth a-mong ICR mice after inoculation of S180 cells, and its immune mechanism as well as its synergic effect in reducing toxicity of cytoxan （CTX）. The experiment was carried out in ICR mice after inoculation of S180 cells. The mice were randomly divided into the model group, the control group, the CTX group, and the drug combination group. After 10 days of medication, the inhibition of tumor growth, WBC, thymus index and spleen index were measured in mice dur-ing the experiment. The immunodepressed mice model was induced by CTX. Effects of ginseng polysaccharide injec-tion on serum hemolysin and monomuclear macrophage phagocytosis were evaluated. The results showed that the com-bination of ginseng polysaccharide injection and CTX can significantly increase the tumor inhibiting rate. It can also reduce the side effect and toxicity of CTX, which may improve the immunosuppression induced by CTX. It was con-cluded that ginseng polysaccharide injection can increase the therapeutic effects and reduce the toxicity of CTX.

关 键 词：人参多糖注射液 环磷酰胺 减毒 S180瘤株ICR小鼠 

分 类 号：R285.5[医药卫生—中药学]