3%高渗盐水和20%甘露醇治疗重型颅脑损伤颅内高压患者的疗效比较  

Comparison of 3% hypertonic saline and 20% mannitol for controlling intracranial pressure in TBI patients

作　　者：高嵘[1] 徐平[1] 刘惠祥[1] 

机构地区：[1]江苏省张家港市第一人民医院神经外科,江苏张家港215600

出　　处：《海南医学院学报》2014年第8期1126-1128,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目~~

摘　　要：目的:探讨3%高渗盐水(HS)和20%甘露醇治疗重型颅脑损伤颅内高压患者的各自疗效。方法:30例重型颅脑损伤颅内高压患者交替使用3%HS和20%甘露醇降颅内压,观察用药后颅内压前后变化,同时观察中心静脉压变化。结果:3%HS和20%甘露醇降颅压效果均明显,但二者比较无明显差异,但经前者治疗后中心静脉压偏低的次数比后者明显少。结论:3%HS和20%甘露醇具有同样的降颅压效果,但用3%HS治疗后能较好地保持中心静脉压处于正常水平,有利于保持血压稳定,提高患者抢救成功率。Objective： To explore effects of 30% HS and 20% mannitol for controlling intracranial pressure in TBI Patients . Methods：30 severe TBI patients were treated by 3 % HS and 20% mannitol alternately for controlling intracranial pressure. Changes of intracraniai pressure after infusion of 3 % HS and 20 % mannitol as well as central venous pressure were observed and compared. Results：Both 3% HS and 20 % mannitol were effective in reducing intracranial pressure but decreased central venous pressure was less frequently observed during 3% HS treatment. Conclusions：The 3 % HS has equal effect as 20 % mannitol in reducing intracranial pressure, but The 3 % HS treatment is more useful for maintaining stable central venous pressure, thus can increase the successful rescue rate of the patients with TBI.

关 键 词：高渗盐水 甘露醇 颅内高压 

分 类 号：R651.1[医药卫生—外科学]