舒芬太尼对兔定量药物脑电图的影响  

Effects of sulfentanil on the band powers of quantitative pharmaco- electroencephalography in rabbits

作　　者：张丹[1] 李贺[2] 徐佳雯[2] 王孝庆[2] 于亚梅[2] 戴体俊[3] 

机构地区：[1]徐州医学院研究生学院2010级,江苏徐州221002 [2]徐州医学院麻醉学院 [3]徐州医学院江苏省麻醉学重点实验室

出　　处：《徐州医学院学报》2014年第7期440-443,共4页Acta Academiae Medicinae Xuzhou

基　　金：国家自然科学基金（30872432,30471657,39970715）;江苏省社会发展科技计划项目（BS200054）;徐州医学院药学院研究生科研创新计划项目（2010YKYCX011）

摘　　要：目的探讨舒芬太尼对兔定量药物脑电图（quantitative pharmaco—electroencephalogram，QPEEG）各频段的影响。方法24只健康成年家兔随机分为4组（n=6）：NS组（生理盐水1ml·kg-1）、LD组（舒芬太尼1．5μg·kg-1）、MD组（舒芬太尼3μg·kg-1）、HD组（舒芬太尼63μg·kg-1）。应用QPEEG，采用功率谱分析，分析兔在静脉注射舒芬太尼前后α1、α2、β1、β2、δ和θ各频段功率百分比的变化。结果与给药前相比，NS组、LD组中β1频段功率百分比无明显变化（P〉0．05），MD组、HD组中各脑区β1频段功率百分比均在30S-30min内减少（P〈0．05，P〈0．01），且较大部分与舒芬太尼剂量呈负相关（r=-0．43～-0．75，P〈0．05）；8频段功率百分比在NS组、LD组与给药前相比也无明显变化，而MD组、HD组中各脑区8频段功率百分比在30s～30min内增加（P〈0．05，P〈0．01），且与舒芬太尼剂量呈明显正相关（r=0．48～0．80，P〈0．01）；各脑区α1、α2、β2和θ频段功率百分比与给药前相比未见明显变化（P〉0．05）。结论舒芬太尼以剂量依赖方式减少兔QPEEGβ1频段功率百分比，同时也以剂量依赖方式增加8频段功率百分比，提示β1和δ频段功率百分比可能成为舒芬太尼镇痛程度的监测指标。Objective To investigate the effects of sulfentanil on the band powers of quantitative pharmaco - electro- encephalography in rabbits. Methods Twenty -four healthy rabbits were randomly divided into four groups, according to their treatment with 1 ml/kg normal saline （NS group）, 1.5, 3 and 6 g/kg sulfentanil （LD, MD and HD groups）. Then the data of QPEEG were collected for analyzing the change of the percentages of α1、α2、β1、β2、δ and θ-band powers before and after sulfentanil treatment. Results Compared with the baseline, there was no obvious change in the NS and LD groups as to the percentage of β1 - band power （P 〉 0.05 ）. The percentage of β1 - band power in each encephalic regions of the MD and HD groups were remarkably decreased from 30 seconds to 30 minutes （ P 〈 0.05 or P 〈 0.01 ）. The change of the percentage of β1 - band power was negatively correlated with the dose of sulfentanil （ r = - 0. 43 - - 0. 75, P 〈 0. 01 ）. Meanwhile, compared with the baseline, there was no remarkable change in the NS and LD groups as to the percentage of δ - band power. The percentage of δ - band power in each encephalic regions of the MD and HD groups were remarkably increased from 30 seconds to 30 minutes （ P 〈 0.05 or P 〈 0.01 ）. The change of the percentage of δ - band power was positively correlated with the dose of sulfentanil （ r = 0. 48～ 0. 80, P 〈 0. 01 ）. No significant difference was found as to the percentage of α1 - , α 2- , β2 - and θ - band power before and after treatment （ P 〉 0.05 ）. Conclusion Sulfentanil treatment can dose - dependently decrease the percentage of β1 - band power of rabbit QPEEG, while increasing the percentage of β1 - band power, which indicates the potential roles that β1 - and δ- band powers take to assess the analgesic effects of sulfentanil.

关 键 词：舒芬太尼 定量药物脑电图 β1频段 Δ频段 镇痛 

分 类 号：R965[医药卫生—药理学]