梗阻性无精子症附睾精子与睾丸精子行ICSI治疗结局比较  

Comparison on intracytoplasmic sperm injection using epididymal and testicular spermatozoa in men with obstructive azoospermia

作　　者：林小民[1] 

机构地区：[1]珠海市妇幼保健院生殖中心,519000

出　　处：《国际医药卫生导报》2014年第15期2298-2300,共3页International Medicine and Health Guidance News

摘　　要：目的 比较梗阻性无精子症应用附睾精子与睾丸精子行卵胞浆内单精子注射技术（ICSI）的临床结局.方法 回顾分析2011年及2012年梗阻性无精子症患者于我中心ICSI助孕110周期,根据精子来源,分为附睾精子组（PESA组）及睾丸精子组（TESA组）,比较两组间的2PN受精率、卵裂率、可移植胚胎率、临床妊娠率、流产率等.结果 2PN受精率TESA组（77.8％）明显低于PESA组（84.5％）（P＜0.05）.TESA组与PESA组的卵裂率（97.1％、97.6％）、可移植胚胎率（74.4％、70.7％）、临床妊娠率（78.6％、67.1％）、流产率（4.6％、7.3％）,两组比较差异均无统计学意义（P＞0.05）.结论 TESA精子用于ICSI治疗2PN受精率比PESA精子低,TESA精子与PESA精子妊娠结局无显著差异.Objective To compare treatment effects of intracytoplasmic sperm injection （ICSI） outcomes using epididymal and testicular spermatozoa in men with obstructive azoospermia.Methods This study retrospectively analyzed 110 azoospermic patients with ICSI cycles who were divided into percutaneous epididymal sperm aspiration （PESA） group and testicular sperm aspiration （TESA） group by the source of sperm.Two groups were compared in the rates of fertilization,cleavage,embryo quality,clinical pregnancy and fetal abortion.Results The 2PN fertilization rate was significantly lower in the TESA group than that in the PESA group （77.8％,84.5％,P ＜ 0.05）.But no statistical significant differences were observed in the rates of cleavage （97.1％,97.6％）,embryo quality （74.4％,70.7％）,clinical pregnancy （78.6％,67.1％）,fetal abortion （4.6％,7.3％） （P ＞ 0.05）.Conclusion TESA-obtained sperm has a lower 2PN fertilization rate than PESA-obtained sperm,both of them have similar pregnancy outcomes.

关 键 词：梗阻性无精子症 经皮附睾精子抽吸术 睾丸精子抽吸术 卵胞浆内单精子注射 

分 类 号：R698.2[医药卫生—泌尿科学]