β_3肾上腺素能受体基因多态性与心血管疾病的研究进展  

Research Progress of β_3 Adrenergic Receptor Gene Polymorphism and Cardiovascular Disease

作　　者：张金宇[1] 杨毅宁[1] 

机构地区：[1]新疆医科大学第一附属医院心脏中心,乌鲁木齐830054

出　　处：《医学综述》2014年第12期2116-2118,共3页Medical Recapitulate

基　　金：教育部"新世纪优秀人才"支持计划(NCET-11-1074)

摘　　要：心血管疾病危害人类健康,其患病率和病死率呈逐年增高的趋势,受到人们的广泛关注。β3肾上腺素能受体(β3AR)是近年来新发现的β肾上腺素能受体,虽然β3AR是主要存在于脂肪组织、胃肠道及肺组织,参与脂解反应和能量调节,在正常心肌组织中表达较少,但与某些心血管疾病的病因、发病机制、药物治疗及预后均有重要关系。该文就β3AR基因多态性与心血管疾病研究进展予以综述。Cardiovascular disease is harmful to human health, and its morbidity and mortality are in a yearly-increasing trend, which is widely concerned. β3 adrenergic receptor（ β3 AR） is a newly discovered beta adrenaline receptors in recent years, the researchers found that although β3 AR mainly exists in the fat, intestinal and lung tissues, participating lipolysis reaction and energy regulation, and shows less expression in normal myocardial muscles, it is closely related to the etiology, pathogenesis, drug treatment and prognosis of cardiovascular diseases. Here is to make a review of the research progress of β3 AR gene polymorphism and cardiovascular diseases.

关 键 词：Β3肾上腺素能受体 心血管疾病 心力衰竭 

分 类 号：R541.4[医药卫生—心血管疾病]