Hepcidin在慢性病贫血中的研究进展  

Research Progress of Hepcidin in Anemia of Chronic Disease

作　　者：曾婷[1] 宋超英[1] 

机构地区：[1]上海交通大学医学院附属新华医院崇明分院血液内科,上海202150

出　　处：《医学综述》2014年第12期2176-2177,共2页Medical Recapitulate

基　　金：崇明县卫生局科研项目(CW2013-02)

摘　　要：慢性病贫血(ACD)是在慢性感染、肿瘤和风湿性疾病等慢性疾病患者中出现的一种贫血,其发病机制目前尚未完全阐明。Hepeidin是调节机体铁稳态的一类抗微生物蛋白物质。越来越多的研究表明,人体铁转运以及铁调素hepcidin在ACD发病中起着不可替代的作用。随着研究不断的深入,针对hepcidin的特异性靶向治疗有望为临床慢性病贫血的防治提供新的思路和方法。Anemia of chronic disease （ACD） is seen in a variety of chronic inflammatory, malignant and rheumatic disease. Its pathogenesis has not been fully elucidated. Hepcidin is an antibacterial polypeptide which plays an important role in regulating iron homeostasis in human body. Functional iron deficiency is fundamental to the pathogenesis of the anemia, and the polypeptide, hepcidin, plays a key role. With further research, hepcidin-speeific targeted therapies for clinical prevention and treatment of ACD is expected to provide new ideas and methods.

关 键 词：慢性病贫血 铁代谢 铁调素 

分 类 号：R556[医药卫生—血液循环系统疾病]