包茎局部狭窄环中胶原纤维分型状况研究  

Research on the classification status of collagen fiber in phimosis stenosis ring

作　　者：孙程[1] 盛新福[1] 张立东[1] 王玉杰[1] 贺继强[2] 

机构地区：[1]新疆医科大学第一附属医院泌尿外科,乌鲁木齐830054 [2]新疆医科大学第一附属医院临床医学系,乌鲁木齐830054

出　　处：《新疆医科大学学报》2014年第9期1170-1171,1175,共3页Journal of Xinjiang Medical University

基　　金：新疆维吾尔自治区自然科学基金(2009211A18)

摘　　要：目的：探讨包茎局部狭窄环中胶原纤维的分型及导致包茎外环口张力过高的主要原因。方法随机选择门诊手术室要求行包皮环切术患者16例，分为正常对照组（8例）和包茎组（8例），年龄8-12岁。取包皮环切手术组织，经固定切片后采取免疫组化法检测Ⅰ型、Ⅱ型、Ⅲ型和Ⅳ型胶原的表达。结果包茎组和正常对照组中均可见Ⅰ型胶原和Ⅲ型胶原明显表达，包茎组中Ⅰ型胶原的含量明显增高，Ⅰ型胶原和Ⅲ型胶原的比例高于正常组（P ＜0．01）。包茎组可见少许Ⅱ型胶原表达，两组Ⅳ型胶原表达均不明显。结论在包茎局部狭窄环中异常堆积的胶原主要为Ⅰ型胶原，Ⅰ型胶原与Ⅲ型胶原的比例过高是导致包茎外环口张力过高的主要原因。Objective To identify the abnormal collagen type in stenosis ring in phimosis and analyze the main reason of leading to phimosis outer ring with high tension.Methods Normal group of 8 cases and phimosis group 8 cases aged 8 to 1 2 .The foreskin after circumcision performed fixed and detected the expression of collagen typeⅠ,collagen typeⅡ,collagen typeⅢ and collagen typeⅣ by immunohistochemistry.Results Collagen Type Ⅰ and collagen type Ⅲ were observed obviously expression in the phimosis group and normal control group.Collagen type Ⅰ increased significantly in the phimosis group.The ratio of collagen type Ⅰ to collagen type Ⅲ is higher than the normal group.In addition,there is a bit of collagen type Ⅱ be found in the phimosis group.Collagen type Ⅳ is not obviously be found in the two group. Conclusion The abnormal collagen type Ⅰ accumulated in the phimosis narrow ring,the higher ratio of collagen type Ⅰ and collagen type Ⅲ may be a major reason of leading to phimosis outer ring with high tension.

关 键 词：Ⅰ型胶原 Ⅲ型胶原 包茎 狭窄环 

分 类 号：R697[医药卫生—泌尿科学]