DABCO离子液体催化Knoevenagel缩合反应  

DABCO based ionic liquid:efficient catalyst for Knoevenagel condensation

作　　者：王政[1] 李志峰[2] 侯海亮 应安国[1] 

机构地区：[1]台州学院医药化工学院,浙江台州318000 [2]天津大学化工学院,天津300072

出　　处：《化学研究》2014年第4期353-358,共6页Chemical Research

基　　金：国家自然科学基金(No.21106090);浙江省低碳脂肪胺工程技术研究中心开放基金(2012E10033);台州学院校立学生科研项目(13XS26;13XS29)

摘　　要：以三乙烯二胺(DABCO)为原料,通过两步法制备了离子液体[DABCO-PDO][PF6];将其用于催化芳香醛与多种活性亚甲基化合物(丙二腈,氰基乙酸乙酯,苯并噻唑乙腈,苯乙腈)的Knoevenagel缩合反应;讨论了可能的反应机理,并基于催化剂的双重催化作用阐述了反应的高效性.结果表明,该反应体系无需任何溶剂,在室温(25℃)下就能进行,催化剂用量小,反应时间短,收率高,反应后处理简单,反应普适性较高;且催化剂重复使用5次后仍保持很高的催化活性.A 1,4-diazabicyclo[2.2.2]octane（DABCO）based ionic liquid[DABCO-PDO][PF6]was prepared through a two-step method.As-prepared[DABCO-PDO][PF6]ionic liquid was used as a catalyst for Knoevenagel condensation of aromatic aldehydes with a variety of active methylene compounds（malononitrile,ethyl-2-cyanoacetate,2-（benzo[d]thiazol-2-yl）acetonitrile,2-phenylacetonitrile）.The possible reaction mechanism was proposed,and the efficiency of the catalytic reaction was interpreted,in relation to the dual catalytic function of the catalyst.It was found that title condensation reaction proceeds smoothly without any solvent at room temperature（25℃）,while the catalyst exhibits a low dosage,a short reaction time and a high yield as well as easy postreatment and broad substrate applicability.Besides,as-prepared catalyst retains high activity after 5times of recycling.

关 键 词：[DABCO-PDO][PF6]离子液体 活性亚甲基化合物 催化 KNOEVENAGEL缩合反应 

分 类 号：O621.25[理学—有机化学]