人芽囊原虫病患者外周血细胞因子测定及其意义  

Determination and Significance of Cytokines in Peripheral Blood of Patients Infected with Blastocystis Hominis

作　　者：陶霖[1] 姜海行[1] 金群馨[1] 唐国都[1] 伍玲园[2] 卢作超[2] 

机构地区：[1]广西医科大学第一附属医院消化内科,南宁市520021 [2]广西医科大学寄生虫教研室,南宁市530021

出　　处：《广西医学》2014年第8期1034-1036,共3页Guangxi Medical Journal

基　　金：广西医药卫生科研课题(Z201013)

摘　　要：目的研究白细胞介素-8(IL-8)、白细胞介素-18(IL-18)、粒-巨噬细胞集落刺激因子(GM-CSF)在人芽囊原虫病中的作用。方法用酶联免疫吸附试验(ELISA)测定30例人芽囊原虫病患者外周血中IL-8、IL-18、GM-CSF水平,并与正常对照组进行比较。结果人芽囊原虫病患者外周血中IL-8、IL-18、GM-CSF水平显著高于正常对照组(P<0.05)。IL-8、GM-CSF水平随感染程度加重而升高(P<0.05)。结论 IL-8、IL-18、GM-CSF可能在人芽囊原虫感染发病中发挥作用。Objective To investigate the role of interleukin-8 （ IL-8 ） , interleukin-18 （ IL-18 ） , granulocyte-macrophage colony-stimulating factor （ GM-CSF ） in Blastocystis hominis .Methods The levels of IL-8 , IL-18 , GM-CSF in peripheral blood of 30 cases of Blastocystis hominis were measured with enzyme-linked immunosorbent assay （ELISA）.And the levels were compared with the normal controls .Results The levels of IL-8,IL-18,GM-CSF in peripheral blood of patients with Blastocystis homini were significantly higher than those of normal control group （P〈0.05）.The levels of IL-8,GM-CSF increased with increasing severity of infection （P 〈0.05）.Conclusion IL-8 ,IL-18 ,GM-CSF may play an important role in the pathogenesis of Blastocystis hominis infection .

关 键 词：人芽囊原虫病 白细胞介素-8 白细胞介素-18 粒-巨噬细胞集落刺激因子 

分 类 号：R381[医药卫生—医学寄生虫学]